Page 52 - Haematologica Vol. 110 - January 2025

PERSPECTIVE ARTICLE
G. Semenzato et al.
The discovery of genetic lesions and/or biological features universally recognized as robust and reliable markers that predict the patients who are or who are not at risk of a subsequent diagnosis of T-LGLL is an unmet clinical need. Studying the temporal longitudinal dynamics of T-CUS with aging, as well as the correlation with clone size, and possibly of subclones, is warranted. However, the small number of rogue cells typically creates a limitation to this approach. Furthermore, the discovery of new dependencies beyond the STAT pathways may reveal new vulnerabilities in leuke- mic cells which could be targeted by innovative strategies. Bridging these gaps would ultimately contribute to over- coming reliance on numerical cutoffs, which are currently the standard criteria to differentiate the benign condition from the T-LGLL-related malignancy. Our understanding of the matter may also be translated into an appropriate diagnostic interpretation that distinguishes T-CUS from T-cell malignancies. This translation, leveraging on specific biological or genetic markers, will bring the field closer to
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Disclosures
No conflicts of interest to disclose.
Contributions
GS led the writing of the article with input from the other authors. All the authors read and approved the final man- uscript.
Funding
GS acknowledges support from the “Associazione Italiana Ricerca contro il Cancro” (AIRC, IG-20216 to GS and IG-29058 to RZ), “Associazione Italiana contro le Leucemie-Linfomi e Mieloma” (AIL), and Italian PNRR funds “National Center for Gene Therapy and Drugs Based on RNA Technology” (Project no. CN00000041 CN3 Spoke #6 “RNA chemistry”).
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