Page 53 - Haematologica Vol. 110 - January 2025

PERSPECTIVE ARTICLE
G. Semenzato et al.
expansions in healthy adults using a new DNA heteroduplex- tracking assay for CDR3 repertoire analysis. J Immunol Methods. 2003;274(1-2):159-175.
20. Ricalton NS, Roberton C, Norris JM, Rewers M, Hamman RF, Kotzin BL. Prevalence of CD8+ T-cell expansions in relation to age in healthy individuals. J Gerontol A Biol Sci Med Sci. 1998;53(3):B196-203.
21. Clambey ET, van Dyk LF, Kappler JW, Marrack P. Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev. 2005;205(1):170-189.
22. van den Beemd R, Boor PP, van Lochem EG, et al. Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry. 2000;40(4):336-345.
23. Effros RB, Dagarag M, Spaulding C, Man J. The role of CD8+ T-cell replicative senescence in human aging. Immunol Rev. 2005;205(1):147-157.
24. Strioga M, Pasukoniene V, Characiejus D. CD8+CD28- and CD8+CD57+ T cells and their role in health and disease. Immunology. 2011;134(1):17-32.
25. Callahan JE, Kappler JW, Marrack P. Unexpected expansions of CD8-bearing cells in old mice. J Immunol. 1993;151(12):6657-6669.
26. Semenzato G, Calabretto G, Barilà G, Gasparini VR, Teramo A, Zambello R. Not all LGL leukemias are created equal. Blood Rev. 2023;60:101058.
27. Marchand T, Lamy de La Chapelle T, Loughran TP. A modern view of LGL leukemia. Blood. 2024;144(18):1910-1923.
28. Morice WG, Cheng CL, Loughran TP Jr, et al. T-large granular lymphocytic leukemia. In: Haematolymphoid Tumours. Edited by The WHO Classification of Tumours Editorial Board, 5th Edition. IARC; 2024. p. 662-664.
29. Calabretto G, Attardi E, Gurnari G, Semenzato G, Voso MT, Zambello R. LGL clonal expansion and unexplained cytopenia: two clues don’t make an evidence. Cancers (Basel). 2022;14(21):5236-5250.
30. De Leval L, Alizadeh AA, Bergsagel PL, et al. Genomic profiling for clinical decision making in lymphoid neoplasms. Blood. 2022;140(21):2193-2227.
31. Teramo A, Gattazzo C, Passeri F, et al. Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. Blood 2013;121(19):3843-3854.
32. Koskela HL, Eldfors S, Ellonen P, et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med. 2012;366(20):1905-1913.
33. Bhattacharya D, Teramo A, Gasparini VR, et al. Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T large granular lymphocyte leukemia. Blood Cancer J. 2022;12(2):31.
34. Barilà G, Teramo A, Calabretto G, et al. STAT3 mutations impact on overall survival in large granular lymphocyte leukemia: a single center experience of 205 patients. Leukemia. 2020;34(4):1116-1124.
35. Muñoz-Garcìa N, Jara-Acevedo M, Caldas C, et al. STAT3 and STAT5B mutations in T/NK-chronic lymphoproliferative disorders of large granular lymphocytes (LGL): association with disease features. Cancers (Basel). 2020;12(12):3508.
36. Shi M, He R, Feldman AL, et al. STAT3 mutations and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia. Human Pathol. 2018;73:74-81.
37. Teramo A, Barilà G, Calabretto G, et al. STAT3 mutation impacts biological and clinical features of T-LGL leukemia. Oncotarget.
2017;8(37):61876-61889.
38. Semenzato G, Zambello R. Interrogating molecular genetics to
refine LGLL classification. Blood. 2022;139(20):3002-3004. 39. Starkebaum G, Loughran TP Jr, Gaur LK, Davis P, Nepom BS.
Immunogenetic similarities between patients with Felty’s syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum. 1997;40(4):624-626.
40. Semenzato G, Calabretto G, Teramo A, et al. The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders. Blood Cancer J. 2024;14(1):13.
41. Schwaneck EC, Renner R, Junker L, et al. Prevalence and characteristics of persistent clonal T cell large granular lymphocyte expansions in rheumatoid arthritis. Arthritis Rheum. 2018;70(12):1914-1922.
42. Gorodetskiy V, Sidorova Y, Biderman B, Kupryshina N, Ryzhikova N, Sudarikov A. STAT3 mutations in “gray zone” cases of T-cell large granular lymphocyte leukemia associated with autoimmune rheumatic diseases. Front Med (Lausanne). 2022;9:1000265.
43. Moon J-S, Younis S, Ramadoss NS, et al. Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis. Nat Commun. 2023;14(1):319.
44. Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica. 2010;95(9):1534-1541.
45. Viny AD, Lichtin A, Pohlman B, Loughran TP, Maciejewski J. Chronic B-cell dyscrasias are an important clinical feature of T-LGL leukemia. Leuk Lymphoma. 2008;49(5):932-938.
46. Loughran TP Jr, Kadin ME, Starkebaum G, et al. Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia. Ann Intern Med. 1985;102(2):169-175.
47. Semenzato G, Pandolfi F, Chisesi T, et al. The lymphoproliferative disease of granular lymphocytes. A heterogeneous disease ranging from indolent to aggressive conditions. Cancer. 1987;60(12):2971-2978.
48. Taylor HG, Terebelo HR, Gamez A. Lymphocytosis in a patient with malignant fibrous histiocytoma. Cancer. 1982;50(8):1563-1567.
49. Zambello R, Loughran TP Jr, Trentin L, et al. Spontaneous resolution of p58/EB6 antigen restricted NK-type lymphoproliferative disease of granular lymphocytes: role of Epstein Barr virus infection. Br J Haematol. 1997;99(1):215-221.
50. Zang R, Shah MV, Loughran TP. The root of many evils: indolent large granular lymphocyte leukemia and associated disorders. Hematol Oncol. 2010;28(3):105-117.
51. Bravo-Perez C, Carrillo-Tornel S, Garcia-Torralba E, Jerez A. Persistent large granular lymphocyte clonal expansions: “The root of many evils”-And some goodness. Cancers (Basel). 2022;14(5):1340.
52. Howard MT, Bejanyan N, Maciejewski JP, Hsi ED. T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations. An unrecognized and frequent association. Am J Clin Pathol. 2010;133(6):936-941.
53. Halapi E, Werner A, Wahlström J, et al. T cell repertoire in patients with multiple myeloma and monoclonal gammopathy of undetermined significance: clonal CD8+ T cell expansions are found preferentially in patients with a low tumor burden. Eur J Immunol. 1997;27(9):2245-2252.
54. Ogbue OD, Kewan T, Bahaj W, Gurnari C, Visconte V, Maciejewski JP. New approaches to idiopathic neutropenia in the era of clonal
Haematologica | 110 January 2025
45