Page 54 - Haematologica Vol. 110 - January 2025

PERSPECTIVE ARTICLE
G. Semenzato et al.
hematopoiesis. Exp Hematol Oncol. 2023;12(1):42.
55. Sidiqi M, Aljama AA, Viswanatha DS, Dingli D. T-cell large granular lymphocytic leukemia and plasma cell disorders. Haematologica.
2019;104(3):e108-110.
56. Braunstein Z, McLaughlin E, Ruiz M, et al. Incidence, treatment,
and survival of patients with T-cell lymphoma, T-cell large granular leukemia, and concomitant plasma cell dyscrasias. Front Oncol. 2022;12:858426
57. Bravo-Perez C, Gurnari C, Kawashima N, et al. LGL and MGUS or MGUS in LGL? Lessons of nature and their clinical implications. Blood. 2023;142(Supplement 1):4769.
58. Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011;118(16):4384-4393.
59. Gattazzo C, Teramo A, Passeri F, et al. Detection of monoclonal T cell populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells. Haematologica. 2014;99(12):1826-1833.
60. Lanasa MC, Allgood SD, Volkheimer AD, et al. Single-cell analysis reveals oligoclonality among low-count monoclonal B-cell lymphocytosis. Leukemia. 2010;24(1):133-140.
61. Au WY, Lam CC, Lie AK, Pang A, Kwong YL. T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. Am J Clin Pathol. 2003;120(4):626-630.
62. Muñoz-Ballester J, Chen-Liang TH, Hurtado AM, et al. Persistent cytotoxic T lymphocyte expansions after allogeneic haematopoietic stem cell transplantation: kinetics, clinical impact and absence of STAT3 mutations. Br J Haematol. 2016;172(6):937-946.
63. Mohty M, Faucher C, Vey N, et al. Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: a long-term analysis. Leukemia. 2002;16(10):2129-2133.
64. Kim DH, Kamel-Reid S, Chang H, et al. Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia. Haematologica. 2009;94(1):135-139.
65. Mustjoki S, Ekblom, M, Arstila TP, et al. Clonal expansion of T/ NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia. 2009;23(8):1398-1405.
66. Kreutzman A, Juvonen V, Kairisto V, et al. Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy. Blood. 2010;116(5):772-782.
67. Rix U, Hantschel O, Durnberger G, et al. Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood. 2007;110(12):4055-4063.
68. Kreutzman A, Ladell K, Koechel C, et al. Expansion of highly differentiated CD8+ T-cells NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia. 2011;25(10):1587-1597.
69. Awada H, Mahfouz RZ, Durrani J, et al. Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation. Br J Haematol. 2020;189(2):318-322.
70. Gao S, Wu Z, Arnold B, Diamon C, et al. Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells. Nat Commun. 2022;13(1):1982.
71. Sandberg Y, Kallemeijn MJ, Dik WA, et al. Lack of common TCRA
and TCRB clonotypes in CD8(+)/TCRaβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. Blood Cancer J. 2014;4(1):e172.
72. Huuhtanen J, Bhattacharya D, Lonnberg T, et al. Single-cell transcriptomics identifies synergistic role of leukemic and non- leukemic immune repertories in CD8+ T cell large granular lymphocytic leukemia. Nat Commun. 2022;13(1):1981.
73. Vicenzetto C, Gasparini VR, Barilà G, et al. Pro-inflammatory cells sustain the leukemic clonal expansion in T-cell large granular lymphocyte leukemia. Haematologica. 2024;109(1):163-174.
74. Sidorova YV, Sychevskaya KA, Chernova NG, et al. High incidence of clonal CD8+ T-cell proliferation in non-malignant conditions may reduce the significance of T-cell clonality assay for differential diagnosis in oncohematology. Clin Lymphoma Myeloma Leuk. 2020;20(4):203-208.
75. Machado HE, Mitchell E, Øbro N, et al. Diverse mutational landscape in human lymphocytes. Nature. 2022;608(7924):724–732.
76. Lundgren S, Myllymaki M, Jarvinen T, et al. Somatic mutations associate with clonal espansions of CD8+ T cells. Sci Adv. 2024;10(23):eadj0787.
77. Kim D, Myllymaki M, Kankainen M, et al. Somatic STAT mutations in CD8+ T cells of healthy blood donors carrying human T-cell leukemia virus type 2. Haematologica. 2022;107(2):550-554.
78. Puente XS, Beà S, Valdés-Mas R, et al. Noncoding recurrent mutations in chronic lymphocytic leukaemia. Nature. 2015;526(7574):519-524.
79. Boiarsky R, Haradhvala NJ, Alberge J-B, et al. Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis. Nat Commun. 2022;13(1):7040.
80. Kleinstern G, Boddicker N, O’Brien DR, et al. Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis. Blood Adv. 2024;8(9):2118-2129.
81. Malcovati L, Galli A, Travaglino E, et al. Clinical significance of somatic mutations in unexplained cytopenias. Blood. 2017;129(25):3371-3378.
82. Masle-Farquhar E, Jackson KJL, Peters TJ, et al. STAT3 gain-of- function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+T cell dysregulation and accumulation. Immunity. 2022;55(12):2386-2404.e8.
83. Schrenk KG, Krokowski M, Feller AC, et al. Clonal T-LGL population mimicking leukemia in Felty’s syndrome–part of a continuous spectrum of T-LGL proliferations? Ann Hematol. 2013;92(7):985-987.
84. Agathangelidis A, Galigalidou C, Scarfò L, et al. Infrequent “chronic lymphocytic leukemia-specific” immunoglobulin stereotypes in aged individuals with or without low-count monoclonal B-cell lymphocytosis. Haematologica. 2021;106(4):1178-1181.
85. Shi M, Morice WG. How I diagnose large granular lymphocytic leukemia. Am J Clin Pathol. 2024;162(5):433-449
86. Greenberg SA, Pinkus JL, Amato AA, Kristensen T, Dorfman DM. Association of inclusion body myositis with T cell large granular lymphocytic leukaemia. Brain. 2016;139(Pt 5):1348-1360.
87. Dutta A, Yan D, Hutchison RE, Mohi G. STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice. Br J Haematol. 2018;180(6):911-915.
Haematologica | 110 January 2025
46