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Letters to the Editor
VIRGINIA RODRÍGUEZ-CORTEZ - vrodriguez@carrerasre- search.org
doi:10.3324/haematol.2021.279047 Received: April 21, 2021.
Accepted: October 19, 2021.
Pre-published: October 28, 2021. Disclosures: no conflicts of interest to disclose.
Contributions:VR-C and MPN-M: conceptualization, methodol- ogy, formal analysis and investigation, writing and preparation of the original draft; OM and TV-H: methodology, formal analysis and investigation; JG, PR, FG-A, HR-H, EK, MV, SR-P and CG-M: methodology; PMa, AB, AT, PP-V and FC-L: resourses; CB and Pme: conceptualization, writing, review and editing, super- vision.
Acknowledgments:the authors would like to thank the staff of the mass spectrometry unit of the scientific and technological services of the University of Barcelona for pesticide metabolite analysis. We are also grateful to the staff at the animal facility of the scientific park of Barcelona for urine collection in metabolic cages.
Funding: this work was supported by CERCA/Generalitat de Catalunya and Fundació Josep Carreras-Obra Social la Caixa through institutional support. Pablo Menendez’s laboratory was supported by the Spanish Ministry of Science and Innovation (PID2019-108160RB-I00 / AEI / 10.13039/501100011033), Retos Colaboración with Banc de Sang i Teixits (RTC-2017-6367- 1), the European Food and Safety Authority (EFSA.PRAS.2018.04-CT1), and the European Research Council. VR-C and MV were supported by Juan de la Cierva fellowships from the Spanish Ministry of Science and Innovation (FJCI-2015- 24303 and IJCI-2017-33172). CB was supported by the Health Institute Carlos III (ISCIII/FEDER PI17/01028 and PI20/00822). PP-V and PN-M were supported by Consejo Nacional de Ciencia y Tecnología (CB-2012-01-183467) and by Fondos del Presupuesto Federal para la Investigación (project 001/2013, Instituto Nacional de Pediatría). JG was supported by Centro de Investigación Biomédica en Red en Cáncer (PID2019-104695RB- I00). TV-H was supported by a Maria Sklodowska-Marie Curie fellowship (792923). OM was supported by a Beatriu de Pinós postdoctoral fellowship (BP2016-00048) from the Generalitat de Catalunya, a Lady Tata award from the Lady Tata Memorial Trust, and an investigator fellowship from the Spanish Cancer Research Association (AECC INVES211226MOLI). SR-P is sup- ported by grants from the Spanish National Research and Development Plan, Instituto de Salud Carlos III, and FEDER (PI17/02303, PI20/01837 and DTS19/00111); AEI/MICIU
EXPLORA Project BIO2017-91272-EXP and AECC_Lab_2020 Project. PM is an investigator of the Spanish Cell Therapy cooper- ative network (TERCEL).
References
1. Infante-Rivard C, Labuda D, Krajinovic M, Sinnett D. Risk of child- hood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology. 1999;10(5):481-487.
2. Ma X, Buffler PA, Gunier RB, et al. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect. 2002;110(9):955-960.
3. Turner MC, Wigle DT, Krewski D. Residential pesticides and child- hood leukemia: a systematic review and meta-analysis. Environ Health Perspect. 2010;118(1):33-41.
4.Navarrete-Meneses MP, Pedraza-Meléndez AI, Salas-Labadía C, Moreno-Lorenzana D, Pérez-Vera P. Low concentrations of perme- thrin and malathion induce numerical and structural abnormalities in KMT2A and IGH genes in vitro. J Appl Toxicol. 2018;38(9):1262- 1270.
5. Navarrete-Meneses MDP, Pérez-Vera P. Pyrethroid pesticide expo- sure and hematological cancer: epidemiological, biological and molecular evidence. Rev Environ Health. 2019;34(2):197-210.
6. Lu C, Liu X, Liu C, et al. Chlorpyrifos induces MLL translocations through caspase 3-dependent genomic instability and topoiso- merase II inhibition in human fetal liver hematopoietic stem cells. Toxicol Sci. 2015;147(2):588-606.
7. Ferreira JD, Couto AC, Pombo-de-Oliveira MS, Koifman S. In utero pesticide exposure and leukemia in Brazilian children < 2 years of age. Environ Health Perspect. 2013;121(2):269-275.
8. Ding G, Shi R, Gao Y, et al. Pyrethroid pesticide exposure and risk of childhood acute lymphocytic leukemia in Shanghai. Environ Sci Technol. 2012;46(24):13480-13487.
9.Borkhardt A, Wilda M, Fuchs U, Gortner L, Reiss I. Congenital leukaemia after heavy abuse of permethrin during pregnancy. Arch Dis Child Fetal Neonatal Ed. 2003;88(5):436-437.
10.Bueno C, Catalina P, Melen GJ, et al. Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells. Carcinogenesis. 2009;30(9):1628-1637.
11. Stanulla M, Wang J, Chervinsky DS, Thandla S, Aplan PD. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation dur- ing the initial stages of apoptosis. Mol Cell Biol. 1997;17(7):4070.
12.Schellenberg MJ, Lieberman JA, Herrero-Ruiz A, et al. ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links. Science. 2017;357(6358):1412-1416.
13. Nanya M, Sato M, Tanimoto K, Tozuka M, Mizutani S, Takagi M. Dysregulation of the DNA damage response and KMT2A rearrangement in fetal liver hematopoietic cells. PLoS One. 2015;10(12):1-18.
14. Aplan PD. Chromosomal translocations involving the MLL gene: molecular mechanisms. DNA Repair (Amst). 2006;5(9-10):1265- 1272.
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