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Letters to the Editor
remaining half of the litter was maintained for 32 weeks for analysis at adulthood (Figure 3A). iFISH analysis revealed that exposure to permethrin or chlorpyrifos during pregnancy failed to induce Mll breaks in bone marrow Lin-Kit+ progenitors from mothers, pups or adult offspring, whereas etoposide exposure induced Mll breaks in a small but significant proportion of Lin-Kit+
progenitors in the mothers and adult offspring, but not in the pups (Figure 3B, C, Online Supplementary Figure S3C).
Finally, we analyzed whether prenatal exposure to etoposide or pesticides affects the hematopoietic home- ostasis of mothers and pups (at weaning) and adult off- spring. Analysis at sacrifice revealed no significant differ-
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BC
DE
Figure 3. Legend on following page
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