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R. Dobson et al.
CD4 PD1 BCL6
CD20 CD30 EBER
CD30
CD20 OCT2 CD4
CD3
Figure 4. Histological and immunophenotypic findings in case 7. The first biopsy shows a subcutaneous perivascular infiltrate of CD3+ T cells with vasculitic features. The third biopsy shows cardinal features of angioimmunoblastic T-cell lymphoma (AITL) and also a prominent pleomorphic infiltrate including an EBER-positive B-cell population with Hodgkin and Reed/Sternberg (HRS)-like morphology and immunophenotype. The fifth biopsy shows no apparent evidence of AITL, but a polymor- phous infiltrate with a more prominent EBER-positive B-cell population that has HRS cell morphology and immunophenotype, rosetting by CD4+ T cells.
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haematologica | 2022; 107(2)