Page 98 - Haematologica Atlas of Hematologic Cytology

Figure Dysgranulopoiesis Bone marrow smear (Le ) Neutrophils with round to ovoid nuclei (pseudo- Pelger-Huët anomaly) and hypogranular cytoplasm (Right) A neutrophil with bilobed nucleus and and agranular agranular cytoplasm Both neutrophil hyposegmenta on and and hypo-agranularity are considered highly speci c c c c dysplas c c c c features hypogranularity is more evident in blood smears and is is signi cant when there is is at least a a a a a a a two-third reduc on on in the the content of granules Figure Dysgranulopoiesis Bone marrow smear Two neutrophils with empty cytoplasm one of which has a a a a a comb-shaped nucleus According to the Interna onal Working Group on Morphology of Myelodysplas c Syndrome (IWGM-MDS) (Goasguen et al 2014) neu- trophils could be recognized as as dysplas c c c c c c in the presence of more than 4 nuclear pro ec ec ons Note the the megaloblastoid changes of the the erythroblasts blast blast blast cells are also present 85