Page 99 - Haematologica Atlas of Hematologic Cytology

CHAPTER 12 - Myelodysplastic syndromes
AB
CD
EF
Figure Dysgranulopoiesis Bone marrow smears (A) Anisocytosis of neutrophils that show giant nuclear seg- ments of bizarre shape (Center) Note a a a a promyelocyte with pink inclusions in in in its cytoplasm (B) A neutrophil with ring nucleus (center) also the the other neutrophils show abnormal nuclear segmentation and hypogranular cytoplasm (C) Most mature neutrophils are of an an an unusually small size and and show nuclear hyposegmentation and and cytoplasmic hypogranularity (D) A dysplastic binucleated macropolycyte (E) Late granulocytic cells with abnor- mal chromatin clumping and decreased secondary granules granules promyelocytes with scanty primary granules granules (F) Hypo-agranularity of of neutrophils can be be better assessed with Sudan black or peroxidase reaction In this case of of myelodysplastic syndrome some neutrophils are negative to Sudan black stain others show reduced sudanophi- lia in comparison with normal neutrophils 86