Page 193 - Haematologica Atlas of Hematologic Cytology

CHAPTER 20 - Congenital dyserythropoietic anemias
AB
Figure 3 Congenital dyserythropoietic anemia type I I Erythroid hyperplasia with megaloblastic changes is a a a a a a a a a a a a a a a constant feature of of bone marrow in in in in in in CDA I I ( ( ) ) Note basophilic stippling in in in in in in the the the cytoplasm of of the the the erythroblast erythroblast in in in in in in the the the center ( ( ) ) Binucleate and multinucleated erythroblasts may be observed usually at at at at a a a a a a a a a a a a a a low frequency These abnormalities are are compatible with the diagnostic suspicion of of CDA I but are are not pathognomonic of of this condition AB
Figure 4 Congenital dyserythropoietic anemia type I I ( and ) An essential feature of CDA I I bone marrow is the presence of chromatin bridges linking two erythroblast nuclei This defect is is specific and has therefore diagnostic significance AB
Figure 5 Congenital dyserythropoietic anemia type I ( and ) Megaloblastic changes are particularly evident in in in these two images Note the the binucleated erythroid precursor in in in B
with nuclei of unequal size and different sta- ges of maturation 180