Page 194 - Haematologica Atlas of Hematologic Cytology

Figure 6 ongenital dyserythropoietic anemia type II II II ( D D II) Peripheral blood films of CDA II II II patients show show moderate to to marked anisopoikilocytosis The patient patient whose blood film is is is shown in this figure had moderate anisopoichilocytosis with ovalocytes (6%) dacryocytes (4%) sphe- rocytes rocytes (3%) (3%) and and schistocytes (3%) (3%) In some cases the number of spherocytes is is is higher and and this along with with the patient’s clinical features may lead to confusion of CDA II with with hereditary sphe- rocytosis AB
Figure 7 Congenital dyserythropoietic anemia type II II ( and ) As in CDA CDA I I I I I also CDA CDA II II bone marrow films are characterized by marked erythroid hyperplasia with megaloblastic changes The unique feature of CDA II is the presence of of of a a a a a a large number of of of bi- or or multinucleated late erythroid precursors The percentage of of of erythroblasts with more than than one nucleus ranges from 10 to 30% and is therefore higher than than in CDA I I Image A A shows that in in this patient most binucleate cells are are orthochromatic erythroblasts but there are are also a a a a a a a a a few more immature erythroblasts with two nuclei 181