Page 105 - Haematologica-April 2018

Metabolic syndrome in childhood leukemia survivors
(considered separately) also differed between the LEA and IPC patients: LEA patients were more likely than IPC sub- jects to have a larger waist circumference [17% vs. 10.6%, respectively, OR=1.79 (95%CI: 1.43-2.23); P<0.001], ele- vated triglycerides [14% vs. 4.5%, respectively, OR=3.59 (95%CI: 2.8-4.6); P<0.001] and high blood pressure [33.9% vs. 22.8%, respectively, OR=1.81 (95%CI: 1.53- 2.14); P<0.001]. By contrast, the prevalence of elevated fasting glucose and low HDL-cholesterol levels were not elevated in the LEA group.
A
The highest prevalence of metabolic syndrome was found in patients who received HSCT (prevalence: 18.8%, OR: 4.87, 95%CI: 3.4-6.99; P<0.001). TBI before HSCT was associated with the highest prevalence of metabolic syndrome (23.2%) as well as the highest relative risk of developing metabolic syndrome (OR=6.26, 95%CI: 4.17- 9.36; P<0.001). Notably, women who received HSCT after TBI were at particularly high risk of developing metabolic syndrome compared with females from the control group [OR=9.25 (95%CI: 5.33-16.1); P<0.001]. Male patients
B
C
Figure 2. Clinical markers. Clinical markers (blood pressure and waist circumference) of metabolic syndrome among Leukemia in Childhood and Adolescents (LEA) cohort patients who show a metabolic syndrome (n=106) according to treatment modality: hematopoietic stem cell transplantation (HSCT) with total body irradiation (TBI): n=39; HSCT without TBI: n=7; no HSCT with central nervous system (CNS) irradiation: n=18; no HSCT/no CNS irradiation: n=42. LEA patients with metabolic syndrome were compared with Investigation and Clinical Prevention (IPC) group patients (controls) with metabolic syn- drome (n=145). Results are expressed as mean±Standard Error of Mean (SEM). (A) Waist circumference. (B) Systolic blood pres- sure. (C) Diastolic blood pressure. *Significant difference,
haematologica | 2018; 103(4)
649