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C.R. Soderquist et al.
haematologica | 2020; 105(7)
Table 2. Immunophenotypic characteristics of gastrointestinal indolent T-cell lymphoproliferative disorders.
Case CD4 CD8 CD2 CD3 CD5 CD7 TIA-1 GrzB Perf CD103 CD56 BCL6 CD10 PD-1 PD-L1 FoxP3 MATK TCRαβ TCRgd CD30 Ki67 T-bet GATA3
1* + - + + -/+ - - - - - - - - - - - - + - -
<5 + -
2* + - + + + + - - - - - - - - - - - + - - 3 + - NA + + + - - - - - NA NA NA - NA - + - - 4*† + - + + +/- - - - - - - - - - - - - +/- - -
5 + + + + + + - - - - - - - + - - - + - -
6 - - + + + -/+ + -/+ NA - - - - + NA - NA + - -
7 - + + + + + - - - + - - - - - - - + - -
8 - + + + + + + +/- - + +/- - - - - - - + - -
9† - + + + - -/+ + - - - - - - - - - - + - - 10 - + + + + + + + - - - - - - - - NA + - -
<5 + + NA - + <5 + + <5 + + <5 -+ <5 - + <5 ++ <5 -+ <5 - +
TOTAL 5/10 5/10 9/9 10/10 8/10 6/10 4/10 2/10 0/9 2/10 1/10 0/9 0/9 2/9 0/9 0/9 0/8 10/10 0/10 0/10 5/10 9/10 (50%) (50%) (100%) (100%) (80%) (60%) (40%) (20%) (0%) (20%) (10%) (0%) (0%) (22%) (0%) (0%) (0%) (100%) (0%) (0%) (50%) (90%)
CD4+ 4/4 0/4 3/3 4/4 3/4 2/4 0/4 0/4 0/4 0/4 0/4 0/3 0/3 0/3 0/4 0/3 0/4 4/4 0/4 0/4 3/4 3/4
(100%) (0%) (100%) (100%) (75%) (50%) (0%) (0%) (0%) (0%) (0%) (0%) (0%) (0%) (0%) (0%) (0%) (100%) (0%) (0%) (75%) (75%) DP 1/1 1/1 1/1 1/1 1/1 1/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 1/1 0/1 0/1 0/1 1/1 0/1 0/1 1/1 1/1
(100%) (100%) (100%) (100%) (100%) (100%) (0%) (0%) (0%) (0%) (0%) (0%) (0%) (100%) (0%) (0%) (0%) (100%) (0%) (0%)
(100%) (100%)
DN 0/1 0/1 1/1 1/1 1/1 0/1 1/1 0/1 NA 0/1 0/1 0/1 0/1 1/1 NA 0/1 NA 1/1 0/1 0/1
0/1 1/1
(0%) (0%) (100%) (100%) (100%) (0%) (100%) (0%) (0%) (0%) (0%) (0%) (100%) (0%) (100%) (0%) (0%)
CD8+ 0/4 4/4 4/4 4/4 3/4 3/4 3/4 2/4 0/4 2/4 1/4 0/4 0/4 0/4 0/4 0/4 0/3 4/4 0/4 0/4 1/4 4/4
(0%) (100%) (100%) (100%) (75%) (75%) (75%) (50%) (0%) (50%) (25%) (0%) (0%) (0%) (0%) (0%) (0%) (100%) (0%) (0%) (25%) (100%)
+: positive; -: negative; DN: double-negative; DP: double-positive; GrzB: granzyme B; NA: not available; Perf: perforin; TCRαβ: T-cell receptor alpha-beta; TCRgd: T-cell receptor gamma-delta.*Previously published cases. †Findings at diagnosis prior to large cell transformation.
(%)
(0%) (100%)