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Clinical features of Rosai-Dorfman disease
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Figure 2. Common imaging findings of Rosai- Dorfman disease on fluorodeoxyglucose (FDG) PET/CT. (A) Maximum intensity projection depict- ing several FDG avid subcutaneous, lymph node and osseous lesions. (B) Coronal fusion images demonstrate FDG avid paranasal sinus (square) and lymph node (circle) disease. (C) Axial fusion image shows an FDG avid subcutaneous soft tis- sue lesion. (D) Sagittal fusion images of the bilat- eral lower extremities demonstrate several FDG avid osseous lesions.
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Figure 3. Cutaneous Rosai-Dorfman Disease (RDD). (A) Petechial rash and subcutaneous nod- ule. (B) Nodular lymphohistiocytic infiltrates in the dermis form a dome shaped lesion. (C) Within a background of small lymphocytes and neutrophils, RDD histiocytes show round nuclei, open chro- matin, central nucleoli, and abundant pale cyto- plasm containing engulfed lymphocytes (emperipolesis). These cells are S100+ by immunohistochemistry (inset). (D) Enhanced coro- nal MRI of the left shoulder depicting a large homogenously enhancing subcutaenous mass (oval). (E) Fused FDG PET/CT of the same patient demonstrating hypermetabolism of this mass (oval).
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