Page 59 - Haematologica Vol. 107 - September 2022
P. 59
ARTICLE - Genetic abnormalities in older ALL patients T. Creasey et al. A
B
C
Figure 4. KDM6A aberrations detected by single nucleotide polymorphism array and next-generation sequencing. KDM6A deletions identified by single nucleotide polymorphism (SNP) array in four patients’ samples (A). Each bar represents a probe on the SNP array. Red colors indicate negative log2 ratio (copy number loss), blue colors represent positive log2 ratio (copy number gain), and white represents no copy number change. Homozygous KDM6A deletion in patient 25437, demonstrating two slightly distinct KDM6A deletions measuring 110 kb and 87 kb, and resulting in biallelic loss of exons 3-6 (B). Small gain also noted following segment of homozygous deletion. KDM6A protein plot displaying two mutations detected by next-generation sequencing (C).
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