Page 244 - Haematologica Vol. 107 - September 2022

LETTER TO THE EDITOR
Abbvie, AstraZeneca, CSL Behring, Janssen, Octapharma, Roche and Takeda outside this work. MNJ is founder and shareholder of Nano1Health S.L.
Contributions
CUN, RS, and TF designed the study; EI, CC and CUN were responsible for sample collection and inclusion of patients; MNJ and RP performed the sequencing; TF, MJ, and CRM performed the bioinformatic and statistical analyses; TF and CUN wrote the first version of the manuscript. All authors read, contributed and approved the final version of the manuscript.
Acknowledgments
The authors would like to express sincere thanks to the patients providing samples for the study and making this kind of research possible. This research would not have been possible without our collaborator, PERSIMUNE Center of Excellence, which provided the infrastructure as well as financial support and exceptional expertise. The staff at the Hematology Department and at the PERSIMUNE biobank at Rigshospitalet were essential for this study as they organized and collected the samples for our research.
References
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2. Larsen N, Vogensen FK, van den Berg FWJ, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PloS One. 2010;5(2):e9085.
3. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457(7228):480-484.
4. Abrahamsson TR, Jakobsson HE, Andersson AF, Björkstén B, Engstrand L, Jenmalm MC. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy. 2014;44(6):842-850.
5. Zitvogel L, Galluzzi L, Viaud S, et al. Cancer and the gut microbiota: an unexpected link. Sci Transl Med. 2015;7(271):271ps1.
6. Uribe-Herranz M, Klein-González N, Rodríguez-Lobato LG, Juan M, de Larrea CF. Gut Microbiota influence in hematological malignancies: from genesis to cure. Int J M Sci. 2021;22(3):1026.
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Computerome team provided computational platform and technical support.
Funding
The study was funded by the Danish Cancer Society (grant R269- A15924) and the Novo Nordisk Foundation (grant NNF16OC0019302). The infrastructure for sampling and analyses was within the Danish National Research Foundation funded PERSIMUNE project (grant 126). The work was also supported by the CLL-CLUE project funded by the European Union.
Data-sharing statement
The datasets generated and analyzed during this study are derived from patients treated in Denmark. The datasets contain sensitive patient data governed by GDPR and Danish law. Due to Danish legislation (Act No. 502 of 23 May 2018) and approvals granted by the Danish Data Protection Agency, it is not possible to upload raw data to a publicly available database. However, access to these data can be made available from the corresponding author on reasonable request, provided a data transfer agreement is entered into according to current regulations.
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11. Wilkins LJ, Monga M, Miller AW. Defining dysbiosis for a cluster of chronic diseases. Sci Rep. 2019;9(1):12918.
12. Cozen W, Yu G, Gail MH, et al. Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins. Br J Cancer. 2013;108(5):1163-1167.
13. Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI. Gut Microbiota and immune system interactions. Microorganisms. 2020;8(10):1587.
14. Ilett EE, Jørgensen M, Noguera-Julian M, et al. Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients. Blood Adv. 2020;4(22):5797-5809.
15. Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP. Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PloS One. 2013;8(8):e70803.
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