Page 167 - Haematologica Vol. 107 - September 2022

ARTICLE - Immune deficiency during RM after transplantation L. Bouard et al.
Figure 1. Infection sites. (A) Graphical repartition of infections sites. (B) Number of infections per infection sites presented with median time of occurrence.
Neutropenia
Concerning neutropenia <0,5x109/L, there was no differ- ence between the two arms for any period, P=0.26, P=0.10, P=0.61 and P=NA, respectively, in chronological order (Table 2). For all patients, the median time of occurrence of neutropenia was located in period 1: 2.40 months (range, 0-30.8 months). However, the median time of oc- currence was significantly delayed in the RM arm: 4.35 months (range, 0.6-19.8 months) versus 1.86 months (range, 0.0-16.1 months) in the Obs arm, P=0.048.
γ globulin levels
Using a 6 g/L cutoff, the difference between the two groups with regards to hypogammaglobulinemia was statistically significant only after 1 year post ASCT, P<0.0001 (Table 2). During period 3, 56 of 107 patients (52.3%) in the Obs arm versus 77 of 99 patients (77.8%) in
RM arm presented at least one event of hypogammaglob- ulinemia, P<0.0001. During period 4, 38 of 89 patients (42.7%) in the Obs arm versus 82 of 97 patients (84.5%) in the RM arm presented at least one event of hypogamma- globulinemia, P<0.0001. Using a 4 g/L cutoff, the difference was statistically significant as from 6 months post ASCT. During period 2, 20 of 116 patients (17.2%) presented hy- pogammaglobulinemia in the Obs arm versus 34 of 104 pa- tients (32.7%) in the RM arm, P=0.0078. During period 3, 16 of 107 patients (15.0%) presented events of hypogam- maglobulinemia in the Obs arm versus 38 of 99 patients (38.4%) in the RM arm, P=0.0001. During period 4, 15 of 89 patients (16.9%) presented events of hypogammaglob- ulinemia in the Obs arm versus 46 of 97 patients (47.4%) and 114 events in the RM arm, P<0.0001. In the Obs and RM arms, Ig median rate changed from 5.11 g/L (range, 2.1- 11.1) to 6.41 g/L (range, 0.6-11.7) and from 4.68 g/L (range,
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