Page 128 - Haematologica May 2022

S. Napoli et al.
Figure 2. GECPAR specific expression in germinal center B cell-like cells and correlation with essential genes. (A) Top: GECPAR expression in a panel of 22 diffuse large B-cell lymphoma (DLBCL) cell lines, 16 germinal center B cell-like (GCB) and 8 activated B cell-like, bottom, expression level of GECPAR antisense transcript, measured as control. (B) Top: box plots of GECPAR expression quantified by total RNA sequencing in normal individuals or GCB- or ABC-DLBCL patients. Bottom: box plots of GECPAR expression in normal individuals stratified for cell of origin. (C) Heat map of differential gene expression, in GCB-DLBCL cell lines dichotomized for GECPAR expression. (D) Preranked gene set enrichment analysis, in GCB-DLBCL cell lines classified for GECPAR expression. (E) Heat map of differential gene expres- sion, in 16 GCB-DLBCL patients, classified for GECPAR expression. (F) Preranked gene set enrichment analysis, in DLBCL patients classified for GECPAR expression
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Figure 3. Legend on following page.
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