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Clonal evolution in relapsed/refractory CLL cases
A
Figure 1. Single nucleotide variants as well as insertions and deletion (Indels) in patients across phases. (A)
B Somatic single nucleotide variants (SNV) and insertions and deletion (Indels) identi- fied in chronic lymphocytic leukemia (CLL) samples (SNV in blue, Indels in green). Genes with recurrent (patients n>2) somatic SNV and Indels identified in our study or CLL drivers from previously pub- lished CLL cohorts highlighted by black boxes (4,26, COSMIC 19/03/14). Only patients with matched control sample were considered. (B) Each symbol shows the number of variants identified in one patient sam- ple. Samples are grouped and colored in dependence of treatment and outcome of the subsequent phase. Black bars
represent group means.
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