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APR-246 induced ferroptosis in AM
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Figure 1. APR-246 induces cell death in acute myeloid leukemia cells irrespective of their TP53 mutational status. (A) Viability curves for the indicated cells at 24 hours (h) post APR-246 treatment. Error bars, ± standard deviation. (B) Viability curves for the indicated primary acute myeloid leukemia (AML) cells at 24 h post APR-246 treatment. Patient characteristics are provided in the Online Supplementary Table S1. (C) Half maximal inhibitory concentration percentage (IC50%) of APR- 246 treatment for 24 h across a panel of AML cell lines based on cell viability (n=3). In our subsequent experiments, we selected five AML cell lines sensitive to APR- 246 in these concentration ranges, with or without TP53 mutations (highlighted in bold font). wt: wild-type; fs: frameshift; del: deletion.
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