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netic and expression changes (Figure 3B). Among the genes with the most striking changes was the C-C motif chemokine receptor 1 (CCR1) gene, a G-protein coupled receptor family member. CCR1 is expressed in different types of blood cells, can bind a number of different ligands
AB
and is induced during normal monocyte development.48 This gene was of specific interest because our previous work had shown that CCL23, a ligand only recognized by CCR1, is also a biomarker for KMT2A-translocated AML.15 RNA-sequencing data from our models and genetically
Figure 3. Legend on following page.
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