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Prognostic relevance of subclonal mutations in ALL
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Figure 3. Potency of RAS pathway mutations to drive clonal expansion. (A-C) Schematic representation of KRAS (A), NRAS (B) and PTPN11 (C) indicating the preva- lence of common hotspot mutations. (D) Violin plot showing allele frequency in hotspot mutations of three investigated RAS pathway genes. The median allele fre- quency was significantly higher in KRAS, indicating a high potential of KRAS hotspot mutations to drive clonal expansion. (E) Violin plot showing allele frequencies in frequent KRAS and NRAS hotspot mutations. The median allele frequency was significantly higher in KRAS G13D, suggesting their higher potential to drive clonal expansion compared to other RAS hotspot mutations.
haematologica | 2021; 106(12)
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