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Prognostic relevance of subclonal mutations in ALL
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Figure 2. Prevalence and distribution of alterations in eight relapse-associated genes. (A) Violin plot showing the variability in mutation allele frequency at diagnosis in the genes studied. The color of the dots indicates whether the mutation was detected in a case without relapse (blue) or with relapse (red). (B) Bar plot showing the frequencies of major clone (high-clonal) and subclonal alterations per case in the genes studied. RAS pathway genes (NRAS, KRAS, PTPN11) were the most fre- quently mutated. Subclonal mutations (yellow bar) were highly prevalent in all genes tested. A subset of cases had both clonal and subclonal alterations in the same gene (gray bar).
haematologica | 2021; 106(12)
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