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L. Paschold et al.
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Figure 3. B lineage repertoire overlaps of paired tissue samples from the same patient. (A) Cohort 2, cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) with relapse. (B) Cohort 3, cases of NLPHL with transformation. Each dot represents a single B-cell clone and is plotted according to its clone fraction at ini- tial diagnosis (x-axis) and at relapse/transformation (y-axis). Dots below the x-axis (gray area) indicate clones present only at initial diagnosis, dots left of the y-axis (gray area) indicate clones present only at relapse/transformation. Shared clones are plotted in the white area. The malignant lymphocyte-predominant cell clone is highlighted in color. In NLPHL34 and NLPHL41 non-identical clones were assumed although the malignant rearrangement at initial diagnosis was not amplified by FR3 primer sets. NLPHL: nodular lymphocyte-predominant Hodgkin lymphoma; DLBCL: diffuse large B-cell lymphoma.
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haematologica | 2021; 106(10)