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Hypoxia signature in BIA-ALCL
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Figure 1. Breast implant-associated anaplastic large cell lymphomas show upregulation of hypoxia-associated genes. (A) Heatmap of genes differentially expressed between breast implant-associated (BIA) anaplastic large cell lymphomas (ALCL) and other ALCL of triple-negative (TN) genetic subtype (lacking rearrangements of ALK, DUSP22 and TP63). A distinct signature of genes overexpressed in BIA-ALCL is seen. Signatures in subgroups of non-BIA ALCL include a keratin (KRT) signature seen in biopsies at epithelial sites (skin and tongue) and a Y-linked signature seen in male patients. See also Online Supplementary Figure S1. (B) Gene set enrich- ment analysis shows upregulation of genes associated with hypoxia in BIA-ALCL. See also Online Supplementary Table S2. NES: normalized enrichment score; FDR: false discovery rate. (C) A volcano plot indicating differentially expressed genes between BIA-ALCL and other TN ALCL. Hypoxia-related genes from HALLMARK HYPOX- IA and SEMENZA HIF1 TARGETS gene sets are indicated in red.
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