Page 209 - 2021_05-Haematologica-web

Effects of absence of PTGS1 in platelets
AD
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Figure 5. Platelet spreading on fibrinogen-coated surfaces. (A) a control, (B) the proband and (C) a homozygous relative with (D) quantification of adhered platelet, filopodia, lamellipodia, fully spread platelet frequency and total platelets per field of view.
Figure 6. Contribution of PTGS1 to eicosanoid synthesis in whole blood and urine. Platelet-derived eicosanoid levels in whole blood from healthy volunteers or from the proband stimulated with collagen (30 mg/mL) (A) or TRAP-6 amide (30 mmol/L) (B). Levels are expressed as increase over levels in vehicle-treated blood. Urinary (C) prostaglandin (PG) D2 and (D) PGE2 (C) PGI2 and (D) thromboxane A2 (TXA2) metabolite levels in proband, homozygous and unaffected relatives. n=4 (healthy vol- unteers); n=1 (proband), n=2 (homozygous relatives), n=3 (unaffected relatives). Normal control ranges are indicated.
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