Page 46 - Haematologica Atlas of Hematologic Cytology

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Figure 2 Plasmodium vivax vivax vivax in in in in a a a a a a a a a a a a a a a a a a a thin blood smear (A) Three RBCs with P P P vivax vivax vivax ring-form trophozoites Ring-forms of P P P vivax vivax vivax have a a a a a a a a a a a a a a a a a a a a a a a a a a a thick cytoplasm cytoplasm and and a a a a a a a a a a a a a a a a a a a a a a a a a a a large chroma n n n n n n n n n n n dot dot As they they mature they they become more compact and and may may acquire an an an an amoeboid shape Moreover the the the the the cytoplasm cytoplasm may may show granules the the the the the so-called Schu Schu ner ner s s s s s s s s s s s s s s s s s s dots dots Infected cells are usually larger than non-infected ones Note surface mbria on on on of the the the erythrocytes and and Schu Schu ner ner s s s s s s s s s s s s s s s s s s s s dots dots (B) RBCs parasi zed by by two P vivax trophozoites trophozoites trophozoites with features that lie somewhere between ring-form ring-form trophozoites trophozoites trophozoites and and and mature mature trophozoi- tes tes tes tes tes The evolu on on of ring-form ring-form trophozoites trophozoites trophozoites trophozoites into mature mature mature ones is marked by by by by a a a a a a a a a a a a a a a a a a a a a a a more compact cytoplasm and and some some mes an an an an amoeboid appearance as as as as seen here (C) A RBC RBC parasi parasi zed zed by by by P P vivax vivax mature mature mature trophozoites trophozoites (D) RBC RBC parasi parasi zed zed by by by a a a a a a a a a a a a a a a a a a a a a a a a a a mature mature mature P P P vivax vivax vivax trophozoite trophozoite trophozoite occupying almost the the the the the en en en en re re re re re cell surface Note Note the the the the the large vacuole and the the the the the ne ne brown pigment pigment content inside inside inside the the the the the the the the cytoplasm cytoplasm (E) RBC RBC parasi parasi parasi zed zed by by a a a a a a a a a a a a a a a a a a a a a a mature mature P P P vivax vivax vivax trophozoite trophozoite Note Note the the the the the the the the ne ne ne dispersed pigment pigment inside inside inside the the the the the parasite and and the the the the the Schu ner s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s ppling inside inside inside the the the the the red cell cytoplasm cytoplasm cytoplasm (F) RBC RBC parasi parasi parasi zed zed by by a a a a a a a a a a a a a a a a a a a a a a a a a P P P vivax vivax vivax macrogametocyte Gametocytes of of of P P vivax vivax are are rounded or or oval-shaped and and show a a a a a a a a a a a a a a a a a a a a a a a a a cytoplasm cytoplasm of of of a a a a a a a a a a a a a a a a a a a a a a a a a di erent intensity of of of blue blue (indeed some mes gray or or or pink) containing ne brown pigment Macrogametocytes are are recognizable from microgametocytes since the the the the the the former usually have a a a a a a a a a a a a a a a a a a a a a a a darker blue blue cytoplasm cytoplasm and and a a a a a a a a a a a a a a a a a a a a a a a compact eccentric chroma n n n n n n n n n n n n n n n n n n n Note the the the the the the pigment inside inside the the the the the the the parasite and and the the the the the the the Schu ner s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s s ppling inside inside the the the the the the the cytoplasm cytoplasm of of the the the the the the the RBC RBC RBC (G) RBC RBC RBC parasi parasi zed by a a a a a a a a a a a a a a a a a a a a a a a P P P vivax vivax vivax microgametocyte (H) Two RBCs showing a a a a a a a a a a a a a a a a a a a P P P vivax vivax vivax schizont schizont A A dis dis nc ve feature of of of P P P vivax vivax vivax schizonts is is is is the the the the the high number number of of of merozoites merozoites An amoeboid pa ern may be be be displayed Chroma n n n n n n n n n n n n n n n is is is is collected in in in two two or or or more masses pigment shapes are found in in one or or or two two clumps Note the high number number of of merozoites merozoites (I) RBC with a a a a a a a a a a P vivax schizont 33