Page 285 - Haematologica Atlas of Hematologic Cytology

CHAPTER 35 - Thrombotic microangiopathies
Figure 1 Thrombo c c microangiopathy (TM )
Peripheral blood lm examina on is an an important diagnos c c c c tool when there is suspicion of TMAs because these condi ons are characterized by thrombocytopenia with di erent degrees of red cell anisopoikilocyto- sis sis In this pa ent with thrombo thrombo c c c c thrombocytopenic purpura the anisopoikilocytosis of the red blood cells cells is very accentuated with cells cells varying greatly in in shape and size Figure 2 Thrombo c c c c c microangiopathy Even under low magni ca ca on we can recognize di erent types of schistocytes
(see Figure 3) microspherocytes dacryocytes and target cells The heterogeneity of of red cell cell shape and size associated with the presence of of schi- stocytes stocytes is is is characteris c c c c c c of of all TMAs The forms with the highest number of of schistocytes
are thrombo thrombo c c c c c thrombocytopenic purpura and hemoly c c c c c uremic syndrome 272