Page 287 - Haematologica Atlas of Hematologic Cytology

CHAPTER 35 - Thrombotic microangiopathies
AB Figure 4 Red blood blood cells cells with with with nuclear nuclear remnants The accelerated erythropoiesis that characterizes thrombo c c c c c c c c c c c c microan- giopathies
may result in in the the the presence in in the the the peripheral blood blood blood of red red cells cells cells with with with nuclear nuclear residues or or even with with with the the the nucleus (A) Four large polychromatophilic polychromatophilic red red red red blood blood blood cells cells cells are to to to to be seen next to to to to normal erythrocytes and microspherocytes One of these polychromatophilic polychromatophilic red red red blood blood cells cells has two Howell-Jolly bodies (B) A A red red red cell cell cell with a a a a a a a a picno c c c c c c c c c c c c c nucleus AB Figure 5 Platelets in in thrombo c c c microangiopathies
(TM ) Peripheral blood lm examina on on con rms that plate- let let count is severely reduced in in TMAs Most platelets are are of a a a a a a a a a normal normal shape and are are normal normal (A) or or or slightly increased in size (B) AB Figure 6 Abnormally shaped platelets platelets platelets platelets Rare platelets platelets platelets platelets reminiscent of of preplatelets (A) and proplatelets (B) may be seen in in in in in blood of of of pa pa ents ents with thrombo thrombo c c c c c c microangiopathies
As in in in in in immune thrombocytopenia these elements are are probably the the the the the expression of of accelerated platelet platelet platelet platelet turnover Preplatelets and proplatelets may be observed also in in in in in some inherited thrombocytopenias but in in in these cases they derive from the the the the defec ve ve ve ve platelet platelet platelet platelet biogenesis caused by gene gene c c c c c c c muta ons 274