Page 259 - Haematologica Atlas of Hematologic Cytology

CHAPTER 31 - Inherited thrombocytopenias
Figure 13 Bone marrow marrow in in inherited thrombocytopenias
Little is known about bone marrow marrow changes in in inherited thrombocytopenias
because this analysis is is is rarely required for diagnostic purposes Because of of the the risk of of developing hematologic malignancies the the forms deriving from mutations in RUNX1 ANKRD26 and ETV6 represent an an exception In these disorders cellularity is is elevated and megakaryocytes are dysmorphic The picture is is similar to that of unilineage mye- lodisplastic syndrome affecting megakaryocytes The figure shows a a a a a a patient with ANKRD26-re- lated thrombocytopenia An abnormally small megakaryocyte can be identified in the center AB Figure 14 Bone marrow in ANKRD26-related thrombocytopenia Clear signs of of dysplasia of of megakaryocytes consisting of of mononucleated and binucleated megakaryocytes megakaryocytes with micromegakaryocytes are typical of of all the inherited thrombocytopenias
predisposing to to to hematologic malignancies 246