Page 257 - Haematologica Atlas of Hematologic Cytology

CHAPTER 31 - Inherited thrombocytopenias
AB Figure 9 Giant platelet granules Mutations in in in FLI1 FLI1 (FLI1-related thrombocytopenia) and large deletions including FLI1 (Paris-Trousseau thrombocytopenia) cause the fusion of -granules and and result in giant ganules (A and and B) Two platelets platelets with one single giant granule This abnormality usually affects a a a a a a a a a very limited proportion of platelets platelets AB Figure 10 Giant platelet granules Paris-Trousseau patient (A) (Upper right corner) Cell with two large granu- les les (Upper left corner) Cell with with no no granules the the other one one (bottom) is normal (B) (Lower right) Platelet with with one one giant and one normal normal size granule granule The other two platelets in the the panel have normal normal granules AB Figure 11 Vacuolated platelets platelets Many enlarged platelets platelets with abundant vacuoles may be observed in GATA1-related disorders and and SRC-related thrombocytopenia A A A and and B describe platelets of a a a a a a a a patient with SRC-re- lated thrombocytopenia Note the large size of platelets 244