Page 260 - Haematologica Atlas of Hematologic Cytology

Figure 15. Bone marrow in ANKRD26-related thrombocytopenia evolved to myelodysplastic syndrome. This patient with congenital thrombocytopenia developed MDS in adulthood. Rich cellularity, with a clear abundance of erythroblasts. According to the 2016 World Health Orga- nization (WHO) classification, the diagnosis of this patient is Myeloid neoplasm with germ line predisposition and pre-existing platelet disorders . In particular, this patient has Myeloid neo- plasm with germ line ANKRD26 mutation .
AB
Figure 16. Bone marrow in ANKRD26-related thrombocytopenia evolved to myelodysplastic syndrome. (A and B) At higher magnification, erythroblasts are clearly dysmorphic, with megaloblastosis and multinucleated cells. Perls staining (B, insert) reveals ring sideroblasts, indicating a diagnosis of acquired refractory anemia with ring sideroblasts. Note in B the degranulation of granulocytic cells.
247