Page 211 - Haematologica Atlas of Hematologic Cytology

CHAPTER 25 - Inherited hemoglobin disorders
Peripheral blood film evaluation plays a a a a a a a a a a a a a ma ma or or role in the diagnosis Peculiarly shaped abnormalities are of dia- gnostic value Common morphological findings of thalassemias are target cells microcytosis anisopoikilocytosis polychromasia moreover dacryocytes (more evident in patients with splenomegaly) erythroblasts and schi- stocytes (in splenectomized patients) are common The sickle-shaped erythrocyte is the hallmark of SCD Laboratory features of thalassemias and SCD are summarized in Table 2 References
Piel FB Steinberg MH Rees DC Sickle-Cell Disease N Engl J Med 2017 376(16):1561-1573 Rees DC Williams TN Gladwin MT Sickle-Cell Disease Lancet 2010 376(9757):2018-2031 Taher AT Weatherall DJ Cappellini MD Thalassaemia Lancet 2018 391(10116):155-167 Weatherall DJ Phenotype genotype relationships in monogenic disease: lessons from the the thalassaemias Nat Rev Genet 2001 2(4):245-255 198