Page 175 - Haematologica Atlas of Hematologic Cytology

CHAPTER 18 - Mature T- and NK-cell neoplasms
Chapter 18. MATURE T- AND NK-CELL NEOPLASMS
Mature T- and natural killer (NK)-cell neoplasms are a heterogeneous group of disorders arising from neopla- stic proliferation of lymphoid cells with mature T or NK phenotype, possibly involving the peripheral blood, bone marrow, lymph nodes, liver, spleen, and skin. A detailed morphological, immunophenotypical and cytogenetic/ molecular examination will enable the correct identification of the clinicopathological entity (Tables 1-3). Mature T- and NK-cell neoplasms include chronic lymphoid leukemias and lymphomas.
Unlike mature B-cell neoplasms, mature T-cell neoplasms often show irregular-shaped nuclei and focal cyto- plasmic reactivity for acid hydrolases; there is also frequent skin involvement.
All small T-cell lymphoid neoplasms may have a leukemic presentation. They have post thymic phenotype; however, their antigenic profile often differs from that of normal mature T lymphocytes. Because immunophe- notypic methods cannot define clonality in T-cell processes, molecular studies of DNA should be performed in problematic cases.
Table 1. 01 orld Health rganiza on classi ca on of mature T and natural iller ( ) cell neoplasms (Swerdlow et al., 2016).
T cell prolymphocy c leu emia
T cell large granular lymphocy c leu emia
hronic lymphoprolifera ve disorder of cells
ggressive cell leu emia
Systemic pstein arr virus ( ) posi ve T cell and cell lymphoprolifera ve diseases of childhood
Systemic EB -posi ve T-cell lymphoma of childhood
Chronic ac ve EB infec on of T- and NK-cell type, systemic form Hydroa vacciniforme-like lymphoprolifera ve disorder
Severe mosquito bite allergy
dult T cell leu emia/lymphoma
xtranodal /T cell lymphoma nasal type
Intes nal T cell lymphoma
Enteropathy-associated T-cell lymphoma
Monomorphic epitheliotropic intes nal T-cell lymphoma
Intes nal T-cell lymphoma, not otherwise speci ed (NOS)
Indolent T-cell lymphoprolifera ve disorder of the gastrointes nal (GI) tract
Hepatosplenic T cell lymphoma
Subcutaneous panniculi s li e T cell lymphoma
Mycosis fungoides
S zary syndrome
Primary cutaneous D 0 posi ve T cell lymphoprolifera ve disorders
Lymphomatoid papulosis
Primary cutaneous anaplas c large cell lymphoma
Primary cutaneous peripheral T cell lymphomas rare subtypes
Primary cutaneous gamma delta T-cell lymphoma
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma* Primary cutaneous acral CD8+ T-cell lymphoma
Primary cutaneous CD4+ small/medium T-cell lymphoprolifera ve disorder
Peripheral T cell lymphoma not otherwise speci ed ( S)
ngioimmunoblas c T cell lymphoma and other nodal lymphomas of T follicular helper cell origin
Angioimmunoblas c T-cell lymphoma
Follicular T-cell lymphoma
Nodal peripheral T-cell lymphoma with T-follicular helper phenotype
naplas c large cell lymphoma L posi ve
naplas c large cell lymphoma L nega ve
reast implant associated anaplas c large cell lymphoma
*Provisional en ty
162