Page 164 - Haematologica Atlas of Hematologic Cytology

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Figure 16 Plasma cell cell cell cell myeloma In In PCM the the the the the the pleomorphism of of of plasma plasma cells cells cells is is mostly due to to the the the the the the fact that they are secre- tory cells cells cells and have abundant endoplasmic endoplasmic re re re re re re re culum culum In In the the the the the the the the ma ma ma ma ma ma ma ma ority of of of normal plasma plasma cells cells cells the the the the the the the the re re re re re re re cular structure of of of the the the the the the the the cytoplasm cytoplasm is is masked by the the the the the the intense basophilic stain in in in in in in PCM the the the the the the endoplasmic endoplasmic re re re re re re re culum culum may may contain condensed or or or or cry- stallized cytoplasmic immunoglobulin and and and the the the re re re re re cular structures may may be clearly visible and and and present striking la la la la la la la ce-like and and and and and crisscross pa erns (A) Increased protein in in in in in in in background with with cellular debris (Right) Plasma Plasma cells cells with with nebulous cytoplasmic cytoplasmic cytoplasmic cytoplasmic cytoplasmic margins margins and and and and cytoplasmic cytoplasmic cytoplasmic cytoplasmic cytoplasmic streamers streamers (B) Plasma Plasma cells cells showing re re re re re re re cular cytoplasmic cytoplasmic cytoplasmic cytoplasmic cytoplasmic structures and and and and pink-red periphery (center) (C) Group of of plasmablasts with irregular cytoplasmic cytoplasmic cytoplasmic cytoplasmic cytoplasmic margins margins cytoplasmic cytoplasmic cytoplasmic cytoplasmic cytoplasmic streamers streamers and and and and crystalline inclusions Plasma cells cells may have long tenuous extensions of of of of cytoplasm cytoplasm cytoplasm which are o o o o o o o o o o o o o o o o o en en en en en fragmented and and and ll ll ll ll ll the the the the back- ground with with cellular debris The peculiar shape of of of the the the the the cells cells is is is is in in in part part due to to to to to the the the the the aspira on on on on on and and and in in in part part to to to to to the the the the the discharge of of of secretory substance substance when the the the the the cytoplasmic membrane is is is is ruptured (D) A giant plasmablast with with with two macronucleoli and and and deeply basophilic cytoplasm cytoplasm cytoplasm with with with immunoglobulin accumula on on on in in in in in the the the the form of of amorphous substance substance or or or or crystals (E (E and and and F) F) Note the the the elongated lance-like (E) and and splinter (F) crystalline structures within the the the cytoplasm cytoplasm of of giant plasmablasts 151