Page 119 - Haematologica Atlas of Hematologic Cytology

CHAPTER 13 - Acute myeloid leukemia and related precursor neoplasms
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Figure cute myeloid leu emia with t( )(p 4 4 1) DEK-NUP214 Bone marrow smear (A) Note a a a a mixture of blasts and basophils at at various stages of matura on (B) Basophilic granules are metachroma c c c with toluidine blue In most cases of acute myeloid leukemia with t(6 9)(p23 q34 1) marrow and peripheral blood basophilia de ned as as as ≥2% basophils is observed Figure 10 cute cute myeloid leu leu emia emia with with inv( )( )( 1 1 1 ) ) ) ) or or t( )( )( 1 1 1 ) ) ) ) GATA2 MECOM Bone marrow Blasts with with with with the morphological features of acute myelomonocy c c c c c c c c c leukemia two small me- gakaryocytes with with with a a a a a a a a a a a a a a a a a a a a a a a a a single non-lobated nucleus and and granular cytoplasm (le ) ) ) ) and and a a a a a a a a a a a a a a a a a a a a a a a a a megakaryocyte with with with two small round nuclei (right) The chromosomal analysis revealed inv(3)(q21 3q26 2) Resul ng ng deregulated MECOM and and and GATA2 expression is is o o o o o o o o o o o o o o o o o en associated with increased increased peripheral blood and/or bone marrow blasts normal or or or elevated platelet counts increased increased dysplas dysplas c c c c c c megakaryocytes and and and mul lineage dysplasia 106