Page 118 - Haematologica Atlas of Hematologic Cytology

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Figure cute promyelocy promyelocy promyelocy c c c c c c c c c leu emia with with a a a a a a a a a a a a a a variant RARA transloca on on on (A) Bone marrow smear showing many hypergranular promyelocytes promyelocytes with with round nuclei and and absence of Auer rods (B) Leukemic promyelocytes promyelocytes are stron- gly reac ve ve ve for Sudan black (le ) ) ) ) ) and and and chloro-acetate esterase (right) The chromosomal analysis revealed t(11 17) (q23 2 2 2 2 q21 2) and and the the molecular inves ga on on the the variant ZBTB16-RARA fusion gene AB
Figure cute myeloid leu emia with with with inv(1 )(p1 )(p1 1 1 1 1 1 1 1 1 1 ) ) ) ) ) or t(1 1 1 1 1 1 1 1 1 1 )(p1 )(p1 1 1 1 1 1 1 1 1 1 ) ) ) ) ) CBFB-MYH11 (A) Bone marrow smear with with with remarkable in in in in in ltra on on on on on by by blasts with with with myelomonocy c c c c c c c c c features There are also many eosinophils at at at at various stages of matura on on on on on characterized by by large basophilic granules as as as as as as as well as as as as as as as speci c c c c c c c c c c c c c c c c c eosinophilic granula ons (B) Moderate or or intense di di use cytoplasmic reac vity of of blast cells for alpha-naphthyl-acetate esterase indica ve of of their monocy c c c c c c c c c c c c c c c commitment AB
Figure cute myeloid leu emia with with t( 11)(p 1 1 1 ) ) ) KMT2A-MLLT3 (A) Bone marrow smear showing me- dium-large sized blasts blasts with with irregular nuclear outlines voluminous nucleoli and abundant some mes nely granu- lated cytoplasm cytoplasm (B) Strong cytoplasmic reac vity for alpha-naphthyl-acetate esterase in in in most blasts blasts This subtype of acute myeloid leukemia is usually associated with monocy c c c c c c c c c features 105