Page 82 - Haematologica-5

S.M. Kornblau et al.
Table 2. List of proteins with reverse correlation to one or more other proteins in acute myeloid leukemia (AML) mesenchymal stromal cells (MSC) versus normal MSC.
Protein
AKT1S1
AKT3 ARC ATF3 BCL2 BCL2L11 BECN1 BID BIRC5 CAV1 CCNB1 CTNNB1
CDK1
CDK4 CREB1 CREB2 p133 DIABLO EGLN1
EIF2S1 p51 ELK1 p383 ERBB2 p1248 ERG
FN1
FOXO1.3/FOXO3 p24.p32 FOXO3
GAB2 p452
GAPDH
GSK3A.B
HDAC3
HNRNPK
HSP90AA1.B1
HSPB1
IRS1 p1101
ITGAL
JMJD6
JUN p73
KIT
LEF1
MAP2K1
MAPK1.3 p202.p204 MAPK9
MAPK14
MS4A1
NPM1
NR4A1
NRP1
PECAM1
AML-MSC negative normal MSC positive
STAT3
BCL2L11, ERG, SFN, SRCp416 STAT3 p727
BCL2, KIT, SFN, TP53 p15 ATF3, CTNNB1
ATF3, CTNNB1 PSMD9, YWHAE GAPDH
MS4A1, FN1, SRC p416
MAPK1.3 p202.p204
BCL2, BCL2L11, FOXO1.3 p24.p32, FOXO3, KIT, ITGAL,
PSMD9 p10, RPS6KB1 p389, SFN, SRC, SRC p416 CREB1
GAPDH, MAPK1.3 p202.p204, YWHAE
CDK1, JUN p73
MAPK9 HSPB1
SMAD1
TCF4
AKT3
BIRC5
CTNNB1
CTNNB1, IRS1 p1101
BID, CDK4, GSK3A.B GAPDH, STK11 PSMD9
DIABLO FOXO3 CTNNB1 STAT3 p727 CREB1
ATF3, CTNNB1 PTK2
CCNB1, CDK4 CREB2 p133 STAT1
BIRC5
PECAM1 JUN p73 NR4A1
AML-MSC positive normal MSC negative
CTNNB1
BIRC5, GAB2 p452
BID, EIF2S1 p51, IRS1 p1101, RPS6KB1 PTK2
ARC, HSP90AA1.B1, MAPK9, PTGS2, YWHAZ
DIABLO, PECAM1, SFN
TP53
CREB1
FOXO1.3 p24.p32, FOXO3, MS4A1, SRC p416, TCF4, YWHAE
BIRC5, TGM2
EGLN1 EGLN1 BID
STAT5A.B CTNNB1
BIRC5
NRP1
XIAP SRC p527 CTNNB1
EGLN1 SMAD1
CREB1
814
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haematologica | 2018; 103(5)