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A. Arvidsson et al.
c8 Cell adhesion
and migration VAV2,VAV3
c9 Vacuolar ATPase and acidification
of cell compartments
c10 Cell-cell signaling
c11 Cholesterol and nuclear
receptors
c12 Proteasome
KEGG focal adhesion, KEGG leukocyte transendothelial migration, Reactome integrin cell surface interactions
KEGG epithelial cell signaling in Helicobacter pylori infection, Reactome iron uptake and transport,
Reactome latent infection of homo sapiens
with mycobacterium tuberculosis
Cell cell signaling
Reactome cholesterol biosynthesis,
Reactome nuclear receptor transcription pathway
Biocarta proteasome pathway, KEGG proteasome,
Reactome activation of NF kappaB in B cells, Reactome antigen processing cross presentation, Reactome CDK mediated phosphorylation and removal of CDC6, Reactome cyclin E associated events during
G1 S transition, Reactome destabilization of mRNA by AUF1 HNRNP D0, Reactome downstream signaling events of B-cell receptor BCR, Reactome ER phagosome pathway, Reactome host interactions
of HIV factors, Reactome regulation of apoptosis, Reactome regulation of mRNA stability by proteins that bind AU rich elements,
Reactome regulation of ornithine decarboxylase ODC,
Reactome signaling by the B-cell receptor BCR,
Reactome VIF mediated degradation of APOBEC3G
Reactome PERK regulated gene expression, Reactome activation of genes by ATF4
KEGG antigen processing and presentation Biocarta Rho pathway
Reactome response to elevated platelet cytosolic CA2, Reactome platelet activation signaling and aggregation
Reactome cytokine signaling in immune system, Reactome IL 3 5 and GM CSF signaling,
Reactome interferon alpha beta signaling,
Reactome interferon gamma signaling,
Reactome interferon signaling, Reactome signaling by ILS
ACTB, ACTG1, ARHGAP5, BCAR1, CTNNA2, MYL12A, PTK2B, RAC2, RAC3, RAP1A, RASSF5, VASP,
ATP6V0A1, ATP6V0B, ATP6V0E1, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, FTL, HMOX2, TFRC
CHRNB1, GCH1, GRIK1, HOMER1, HPRT1, HTR2C, KCNMB2, KLF10, MPZ, NMB, POMC, SRI, SYPL1, ZYX
CYP51A1, DHCR7, FDFT1, HMGCR, HMGCS1, HSD17B7, IDI1, IDI2, MSMO1, MVD, MVK, NR4A2, RARA, RARG, SQLE
AKT3, AP2S1, ARF1, ATP6V1H, BAD, BANF1, CASP9, ELMO1, FBXW11, GRB2, HCK, IKBKB, KPNA1, MLST8, NPM1, NR4A1, NRAS, NUPL1, PACS1, PPIA, PRKCB, PSMA1, PSMA4, PSMA7, PSMA8, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB8, PSMB9, PSMC3, PSMC4, PSMC5, PSMD11, PSMD12, PSMD13, PSMD14, PSMD3, PSMD4, PSMD7, PSMD8, PSMD9, RAN, RASGRP1, RASGRP3, RELA, RPS27A, SHC1, SKP1, SLC25A5, TCEB1, TCEB2, THEM4, TRIB3
ASNS, ATF3, ATF4, ATF6, DDIT3, EIF2S1, EXOSC1, EXOSC3, EXOSC4, EXOSC7, EXOSC9, HERPUD1, NFYA
B2M, CANX, CTSB, HLA-A, HLA-C, HLA-DMA,
HLA-DMB, HLA-DPA1, HLA-DRB4, HSPA4, PSME3, RFX5
ACTR3, ARHGAP6, ARPC1B, ARPC2, ARPC3, ARPC5, CFL1, DIAPH1, GSN, PIP5K1A, PIP5K1B
ABCC4, CD63, DGKG, DGKH, HSPA5, PFN1, PLEK, STX4, TMSB4X, TUBA4A, WDR1
CD44, CIITA, CISH, EIF4E, EIF4G2, FYN, IFI35,
IFITM1, IFITM2, IFNGR1, IFNGR2, IL2RA, IL2RG,
IRF2, IRF4, JAK2, JAK3, KPNA4, LCK, LYN, MAP3K8,
MX1, NUP153, NUP35, NUP37, NUP54, OAS3, PTPN6,
SEH1L, STAT1, STAT3, STAT5A, STAT5B, TNIP2, TOL LIP, UBE2L6, USP18, VAV1, YES1
c13 Endoplasmic reticulum stress
and exosome
c14 MHC/ antigen presentation
c15 Actin cytoskeleton remodeling
c16 Cytoskeleton remodeling/ vesicle
docking
c17 Cytokine signaling and nucleus
cytoplasm transport
Functional clusters for which gene transcripts are less abundant in adherent MCL cells compared to suspension MCL cells in the same co-culture
c18 Histones
c19 Cell cycle M phase
c20 Δp63 signaling pathway
Reactome meiosis, Reactome meiotic recombination, Reactome amyloids, Reactome RNA POL I promoter opening, Reactome deposition of new CENPA containing nucleosomes at the centromere
M phase, Mitosis, M phase of mitotic cell cycle, PID PLK1 pathway
PID delta NP63 pathway
DIDO1, DMC1, HIST1H2AC,
HIST1H2BD, HIST1H2BF, HIST1H2BG, HIST1H2BO, HIST1H3B, HIST1H3D, HIST1H3E,
HIST1H3G, HIST1H3H, HIST1H4J, HIST1H4K, HIST2H2AA4, HIST2H2BE, HIST2H4A, HIST4H4, MSH5, SUN2, SYNE1, SYNE2
ANLN, ATM, AURKA, BIRC5, BRSK1, BUB1, BUB1B,
CDC25B, CDC25C, CENPE, CIT, DLGAP5, EGF, ESPL1, KIF11, KNTC1, NEK2, NUMA1, PLK1, RAD52, TAF1L, TPX2, TTK, XRCC2
ADA, BDKRB2, BRCA2,
CCNB2, FASN, HBP1, MRE11A, NRG1, RAB38, STXBP4, TOP2A
haematologica | 2018; 103(4)