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G. Kooij et al.
Table 2. Human plasma lipid mediator (LM) (pg/mL).
AA bioactive metabolome Q1 Q3 AA 303 259 LTB4 335 195 20-OH-LTB4 351 195 20-COOH-LTB4 365 195 5S,12S-diHETE 335 195 5S,15S-diHETE 335 115
PGD2 351 233 PGE2 351 189 PGF2a 353 193 TBX2 369 169
5-HETE 319 115 12-HETE 319 179 15-HETE 319 219
LXA4 351 115 LXB4 351 221 AT-LXA4 351 115 AT-LXB4 351 221
DHA bioactive metabolome
DHA 327 283 RvD1 375 121 RvD2 375 215 RvD3 375 147 RvD4 375 101 RvD5 359 199 RvD6 359 101 AT-RvD1 375 121 AT-RvD3 375 147
PD1 359 153 AT-PD1 359 153 PDX
Maresin1 359 221
17-HDHA 343 245 14-HDHA 343 205 4-HDHA 359 101 7-HDHA 359 250
EPA bioactive metabolome
EPA 301 259 RvE1 349 195 RvE2 333 253 RvE3 333 201
18-HEPE 317 259 15-HEPE 317 219 12-HEPE 317 179 5-HEPE 317 115
13940 ± 1942 32.79 ± 11.55 -
- 21.04 ± 11.04 10.78 ± 5.02
1.69 ± 0.44 3.84 ± 1.22 8.55 ± 3.14 63.14 ± 20.03
199.6 ± 39.91 657.10 ± 145.50 56.98 ± 14.84
0.65 ± 0.56 1.64 ± 0.44 3.56 ± 1.69
12480 ± 811.1 63.16 ± 16.25 -
-
64.11 ± 40.07 47.30 ± 14.48
8.42 ± 1.63 16.37 ± 2.68 14.74 ± 1.69 209.60 ± 40.96
345.20 ± 97.29 1472.00 ± 180.20 102.70 ± 11.85
1.85 ± 0.88 4.71 ± 1.66 6.57 ±1.59
0.4127 0.2958 - - 0.2406 0.1336
0.0211 0.0098 0.0768 0.0289
0.1588 0.0095 0.0348
0.4077 0.2705 0.2797 -
0.6247
0.2735
HS MS P
--
25330.00 ± 3090.00 22690.00 ± 3133.00 0.19 ± 0.09 0.68 ± 0.32
- - - - - - - - -
0.38 ± 0.15
1.37 ± 0.43 0.1794
0.02 0.43
- - -
± 0.01 −
± 0.15
- - - - - -
0.14 ± 0.03 0.0325 −
2.08 ± 0.65 0.1182
- - -
71.47 ± 17.66 310.20 ± 91.26 30.19 ± 6.94 5.68 ± 1.29
6605.00 ± 1296.00
75.50 ± 28.23 18.54 ± 5.76 244.70 ± 66.11 27.07 ± 7.79
114.70 ± 12.40 784.90 ± 130.90 69.51 ± 18.37 7.23 ± 1.06
49.89 ± 8.10
17.85 ± 2.32 393.70 ± 49.88 30.16 ± 6.90
0.0588 0.0333 0.1810 0.4185
0.0472
0.2445 0.6215 0.0895 0.7989
4606.00 ± 341.80
- - - - - - - - -
HS: healthy subjects; MS: multiple sclerosis.
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haematologica | 2020; 105(8)