Page 183 - 2020_02-Haematologica-web

Allogeneic transplantation for -5/5q- AML
Figure 1. Additional cytogenetic abnormalities. Distribution of additional cytogenetic abnormalities. Only 47 patients harbored -5/5q- without -7/7q-, CK, MK or abn(17p). The vast majority of the patients showed a CK (87%) and/or MK (67%) in combination with -5/5q-. The main groups were the combination of CK, MK and abn(17p), the association of MK and CK and the patients with CK. The dark blue circles illustrate patients with -7/7q- among the different cytogenetic groups.
Table 2. Univariate analysis of additional cytogenetic abnormalities.
RI
NRM P 2y (%, 95%CI)
LFS 2y (%, 95%CI)
OS
GRFS
0.001
0.002
0.0002
0.01
0.73
0.04
0.04
2y (%, 95%CI)
CK
Yes 62 (57-67) No 44 (31-56)
MK
Yes 64 (57-69) No 51 (43-59)
Abn(17p)
Yes 66 (58-72) No 56 (50-62)
-7/7q-
Yes 62 (54-68) No 59 (53-64)
Abn3q26
Yes 68 (37-87) No 60 (55-64)
Abn11q23
Yes 54 (37-69) No 60 (56-65)
P
0.7
0.56
0.44
0.36
0.92
0.95
P
0.0007
0.0001
<0.0001
0.02
0.24
0.21
2y (%, 95%CI)
22 (18-27) 56 (44-69)
22 (17-27)
38 (30-46)
16 (11-22) 34 (28-39)
20 (14-26)
31 (26-37)
13 (0-29) 28 (23-32)
35 (18-51)
26 (22-30)
P
<0.0001
0.0003
<0.0001
0.002
0.16
0.18
2y (%, 95%CI)
11 (8-14) 26 (15-37)
10 (7-14)
19 (13-26)
7 (3-10) 17 (13-22)
10 (6-14)
15 (11-19)
19 (0-38) 13 (10-16)
19 (7-32)
13 (9-16)
P
0.004 20 (16-24) 19 (11-30)
0.0004 20 (15-24)
21 (15-28)
0.02 22 (16-28) 19 (15-24)
0.28 22 (16-28)
19 (15-24)
0.23 15 (3-35) 20 (17-24)
0.42 19 (8-34)
20 (16-24)
18 (14-21) 37 (25-49)
16 (12-20)
28 (21-36)
13 (8-18) 25 (20-30)
17 (11-22)
22 (17-27)
16 (0-35) 20 (17-24)
26 (12-41)
20 (16-23)
CK: complex karyotype; MK: monosomal karyotype; abn(17p): 17p abnormalities; -7/7q-: monosomy 7 or deletion 7q; abn3q26: abnormalities of chromosome 3q26; abn11q2: abnormalities of 11q2; RI: relapse incidence; 2y: 2 years; CI: confidence interval; NRM: non-relapse mortality; LFS: leukemia-free survival; OS: overall survival; GRFS: graft-versus- host disease and relapse-free survival.
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