Page 47 - 2020_01-Haematologica-web

Intrinsic HSC aging
the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2008;2(4):356- 366.
153. Mancini SJ, Mantei N, Dumortier A, Suter U, MacDonald HR, Radtke F. Jagged1- dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005;105(6):2340- 2342.
154.Benveniste P, Serra P, Dervovic D, et al. Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. Blood. 2014;123(8):1167-1177.
155. Anjos-Afonso F, Currie E, Palmer HG, Foster KE, Taussig DC, Bonnet D. CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell. 2013;13(2):161-174.
156. Spencer NF, Poynter ME, Im SY, Daynes RA. Constitutive activation of NF-kappa B in an animal model of aging. Int Immunol. 1997;9(10):1581-1588.
157.Zhou J, Ching YQ, Chng WJ. Aberrant nuclear factor-kappa B activity in acute myeloid leukemia: from molecular patho- genesis to therapeutic target. Oncotarget. 2015;6(8):5490-5500.
158. Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007;21(24): 3244-3257.
159.Salminen A, Hyttinen JM, Kauppinen A, Kaarniranta K. Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process. Int J Cell Biol. 2012;2012:849541.
160.Chen Z, Amro EM, Becker F, et al. Cohesin- mediated NF-κB signaling limits hematopoi- etic stem cell self-renewal in aging and inflammation. J Exp Med. 2019;216(1):152- 175.
haematologica | 2020; 105(1)
37