Page 45 - 2020_01-Haematologica-web
P. 45

Intrinsic HSC aging
Vilchez D. Mechanisms of protein home- ostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells. Cell Mol Life Sci. 2018;75(2):275-290.
38. Chapple RH, Hu T, Tseng YJ, et al. ERalpha promotes murine hematopoietic regenera- tion through the Ire1alpha-mediated unfold- ed protein response. Elife. 2018;7.
39. Moran-Crusio K, Reavie LB, Aifantis I. Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system. Trends Immunol. 2012;33(7):357-363.
40. Fleming HE, Janzen V, Lo Celso C, et al. Wnt signaling in the niche enforces hematopoiet- ic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell. 2008;2(3):274-283.
41. Blank U, Karlsson S. TGF-beta signaling in the control of hematopoietic stem cells. Blood. 2015;125(23):3542-3550.
42. Lampreia FP, Carmelo JG, Anjos-Afonso F. Notch Signaling in the Regulation of Hematopoietic Stem Cell. Curr Stem Cell Rep. 2017;3(3):202-209.
43. Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007;5(8):e201.
44. Florian MC, Nattamai KJ, Dorr K, et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature. 2013;503(7476):392-396.
45. Quere R, Saint-Paul L, Carmignac V, et al. Tif1gamma regulates the TGF-beta1 recep- tor and promotes physiological aging of hematopoietic stem cells. Proc Natl Acad Sci U S A. 2014;111(29):10592-10597.
46. de Renty C, Ellis NA. Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. Ageing Res Rev. 2017;33:36-51.
47. Parmar K, Kim J, Sykes SM, et al. Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells. 2010;28(7):1186-1195.
48. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007;447(7145):725-729.
49. Wahlestedt M, Erlandsson E, Kristiansen T, et al. Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent inter- mediate. Nat Commun. 2017;8:14533.
50. Osorio FG, Rosendahl Huber A, Oka R, et al. Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis. Cell Rep. 2018;25(9):2308-2316.
51. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 1998;273(10):5858- 5868.
52. Moehrle BM, Nattamai K, Brown A, et al. Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs. Cell Rep. 2015;13(11):2412- 2424.
53. Beerman I. Accumulation of DNA damage in the aged hematopoietic stem cell com- partment. Semin Hematol. 2017;54(1):12-18.
54. Busque L, Patel JP, Figueroa ME, et al. Recurrent somatic TET2 mutations in nor- mal elderly individuals with clonal hematopoiesis. Nat Genet. 2012;44(11): 1179-1181.
55. Genovese G, Kahler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N
Engl J Med. 2014;371(26):2477-2487.
56. Jaiswal S, Fontanillas P, Flannick J, et al. Age- related clonal hematopoiesis associated with adverse outcomes. N Engl J Med.
2014;371(26):2488-2498.
57. Challen GA, Sun D, Mayle A, et al. Dnmt3a
and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014;15(3):350-364.
58. Zhang X, Su J, Jeong M, et al. DNMT3A and TET2 compete and cooperate to repress lin- eage-specific transcription factors in hematopoietic stem cells. Nat Genet. 2016;48(9):1014-1023.
59. Nagase R, Inoue D, Pastore A, et al. Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 2018;215(6):1729-1747.
60. Buscarlet M, Provost S, Zada YF, et al. DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phe- notypes and different genetic predisposi- tions. Blood. 2017;130(6):753-762.
61. Cargo CA, Rowbotham N, Evans PA, et al. Targeted sequencing identifies patients with preclinical MDS at high risk of disease pro- gression. Blood. 2015;126(21):2362-2365.
62. Young AL, Challen GA, Birmann BM, Druley TE. Clonal haematopoiesis harbour- ing AML-associated mutations is ubiquitous in healthy adults. Nat Commun. 2016; 7:12484.
63. Behrens A, van Deursen JM, Rudolph KL, Schumacher B. Impact of genomic damage and ageing on stem cell function. Nat Cell Biol. 2014;16(3):201-207.
64. Shepherd BE, Kiem HP, Lansdorp PM, et al. Hematopoietic stem-cell behavior in nonhu- man primates. Blood. 2007;110(6):1806-1813.
65. Whittemore K, Vera E, Martínez-Nevado E, Sanpera C, Blasco MA. Telomere shortening rate predicts species life span. Proc Natl Acad Sci U S A. 2019;116(30):15122-15127.
66. Harrison DE, Astle CM. Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and trans- plantation procedure. J Exp Med. 1982;156 (6):1767-1779.
67. Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT over-expression on the long-term transplan- tation capacity of hematopoietic stem cells. Nat Med. 2003;9(4):369-371.
68. Sekulovic S, Gylfadottir V, Vulto I, et al. Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells. Blood. 2011;118(7):1766-1773.
69. Raval A, Behbehani GK, Nguyen lX, et al. Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. PLoS One. 2015;10(7):e0131722.
70. Wang J, Lu X, Sakk V, Klein CA, Rudolph KL. Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telom- eres. Blood. 2014;124(22):3237-3240.
71. Townsley DM, Dumitriu B, Young NS. Bone marrow failure and the telomeropathies. Blood. 2014;124(18):2775-2783.
72. Hosokawa K, MacArthur BD, Ikushima YM, et al. The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age. Nat Commun. 2017;8(1):804.
73. Yu KR, Espinoza DA, Wu C, et al. The impact of aging on primate hematopoiesis as interrogated by clonal tracking. Blood. 2018;131(11):1195-1205.
74. Xu J, Wang Y, Guttorp P, Abkowitz JL.
Visualizing hematopoiesis as a stochastic
process. Blood Adv. 2018;2(20):2637-2645. 75. Rozhok AI, DeGregori J. The evolution of lifespan and age-dependent cancer risk.
Trends Cancer. 2016;2(10):552-560.
76. Li Z, Cai X, Cai CL, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011;118(17):
4509-4518.
77. Almosailleakh M, Schwaller J. Murine
Models of Acute Myeloid Leukaemia. Int J
Mol Sci. 2019;20(2).
78. Wahlestedt M, Norddahl GL, Sten G, et al.
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. Blood. 2013;121 (21):4257-4264.
79. Grover A, Sanjuan-Pla A, Thongjuea S, et al. Single-cell RNA sequencing reveals molecu- lar and functional platelet bias of aged haematopoietic stem cells. Nat Commun. 2016;7:11075.
80. Wahlestedt M, Bryder D. The slippery slope of hematopoietic stem cell aging. Exp Hematol. 2017;56:1-6.
81. Gonzalo S. Epigenetic alterations in aging. J Appl Physiol (1985). 2010;109(2):586-597.
82. Taiwo O, Wilson GA, Emmett W, et al. DNA methylation analysis of murine hematopoietic side population cells during aging. Epigenetics. 2013;8(10):1114-1122.
83. Brinkman AB, Gu H, Bartels SJ, et al. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk. Genome Res. 2012;22(6):1128-1138.
84. Jones MJ, Goodman SJ, Kobor MS. DNA methylation and healthy human aging. Aging Cell. 2015;14(6):924-932.
85. Kramer A, Challen GA. The epigenetic basis of hematopoietic stem cell aging. Semin Hematol. 2017;54(1):19-24.
86. Lee SC, Miller S, Hyland C, et al. Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell func- tion and lymphopoiesis. Blood. 2015;126(2): 167-175.
87. Xie H, Xu J, Hsu JH, et al. Polycomb repres- sive complex 2 regulates normal hematopoi- etic stem cell function in a developmental- stage-specific manner. Cell Stem Cell. 2014;14(1):68-80.
88. Cellot S, Hope KJ, Chagraoui J, et al. RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. 2013;122(9): 1545-1555.
89. Thieme S, GyárfásT, Richter C, et al. The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood. 2013;121(13):2462-2473.
90. Kerenyi MA, Shao Z, Hsu YJ, et al. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2013;2:e00633.
91. Djeghloul D, Kuranda K, Kuzniak I, et al. Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation. Stem Cell Rep. 2016;6(6): 970-984.
92. Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science. 2006;311 (5762):844-847.
93. Kaufmann KB, Garcia-Prat L, Liu Q, et al. A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency. Blood. 2019;133(20):2198-2211.
94. Abo A, Qu J, Cammarano MS, et al. PAK4, a
haematologica | 2020; 105(1)
35


































































































   43   44   45   46   47