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X. Li et al.
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Figure 3. CUDC-907 treatment inactivates PI3K and ERK and causes downregulation of Mcl-1, CHK1, Wee1, and RRM1, and upregulation of Bim and γH2AX. (A-C) Acute myeloid leukemia (AML) cell lines and primary AML samples were treated with CUDC- 907 for 24 h. Whole cell lysates were subjected to western blot- ting. The fold changes for the den- sitometry measurements, nor- malized to β-actin and then com- pared to no drug control, are indi- cated below the corresponding blot. Bim S, L, and EL indicate Bim short, long, and extra-long isoforms, respectively. (continued on the next page).
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haematologica | 2019; 104(11)