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Performance of AL cardiac staging systems
Impaired renal function and atrial arrhythmias add prognostic information to the staging systems
To further evaluate whether, and if so to what extent, eGFR<50 and AF add prognostic information to the dif- ferent staging systems, we performed multivariable sur- vival analyses for each staging system. Age as well as dFLC (except in conjunction with the MAYO2012 stag-
A
ing system) were also included, as these factors had been found to be highly prognostic in the univariable analyses (Table 2). While eGFR<50 retained its prognostic value at the significance level of 5% in multivariable analyses with the MAYO2004 and MAYO2012 staging systems, it was not significant in multivariable analysis with the MAYO3b system, suggesting an improved prognostica-
B
C
Figure 2. Overall survival according to the staging systems. Kaplan-Meier-Plots. pairwise P-values and median overall survival are given in Online Supplementary Table S5. Shaded areas indicate the 95% confidence intervals. (A) All patients. (B) Subgroup of patients with an estimated glomerular filtration rate <50 mL/min/1.73 m2. (C) Subgroup of patients with atrial arrhythmia or pacemaker rhythm.
haematologica | 2019; 104(7)
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