Page 61 - 2019_04-Haematologica-web

Iron excretion in iron excess
22. Gelderman MP, Baek JH, Yalamanoglu A, et al. Reversal of hemochromatosis by apo- transferrin in non-transfused and trans- fused Hbbth3/+ (heterozygous b1/b2 glo- bin gene deletion) mice. Haematologica. 2015;100(5):611–622.
23. Guo S, Casu C, Gardenghi S, et al. Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. J Clin Invest. 2013;123(4):1531–1541.
24. Ramos E, Ruchala P, Goodnough JB, et al. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012;120(18): 3829–3836.
25. Schmidt PJ, Toudjarska I, Sendamarai AK, et al. An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood. 2013;121(7):1200–1208.
26. Green R, Charlton R, Seftel H, et al. Body iron excretion in man: a collaborative study. Am J Med. 1968;45(3):336–353.
27. Casu C, Nemeth E, Rivella S. Hepcidin ago- nists as therapeutic tools. Blood. 2018;131(16):1790–1794.
28. Cheng H, Bjerknes M. Cell production in mouse intestinal epithelium measured by stathmokinetic flow cytometry and Coulter particle counting. Anat Rec. 1983;207(3):427–434.
29. Creamer B, Shorter RG, Bamforth J. The turnover and shedding of epithelial cells. I. The turnover in the gastro-intestinal tract. Gut. 1961;2110–118.
30. Williams JM, Duckworth CA, Burkitt MD, Watson AJM, Campbell BJ, Pritchard DM. Epithelial cell shedding and barrier func- tion: a matter of life and death at the small intestinal villus tip. Vet Pathol. 2015;52(3): 445–455.
31. Pountney DJ, Konijn AM, McKie AT, et al. Iron proteins of duodenal enterocytes iso- lated from mice with genetically and exper- imentally altered iron metabolism. Br J Haematol 1999;105(4):1066–1073.
32. Oates PS, Jeffrey GP, Basclain KA, Thomas C, Morgan EH. Iron excretion in iron-over- loaded rats following the change from an iron-loaded to an iron-deficient diet. J Gastroenterol Hepatol. 2000;15(6):665–674.
33. Marques TG, Chaib E, da Fonseca JH, et al. Review of experimental models for induc-
ing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection. Acta Cir Bras. 2012;27(8):589–594.
34. Bláha K, Cikrt M, Nerudová J, Ponka HF. Biliary iron excretion in rats following treatment with analogs of pyridoxal isoni- cotinoyl hydrazone. Blood. 1998;91(11): 4368–4372.
35. Goss JA, Barshes NR, Karpen SJ, Gao F-Q, Wyllie S. Liver ischemia and ischemia- reperfusion induces and trafficks the multi- specific metal transporter Atp7b to bile duct canaliculi: possible preferential trans- port of iron into bile. Biol Trace Elem Res. 2008;122(1):26–41.
ganese load on the rate of excretion of cop- per, iron and zinc in bile. Br J Nutr. 1981;45(3):605–611.
45. Symonds HW, Mather DL, Hall ED. Surgical procedure for modifying the duo- denum in cattle to measure bile flow and the diurnal variation in biliary manganese, iron, copper and zinc excretion. Res Vet Sci. 1982;32(1):6–11.
46. Deol HS, Howell JM, Dorling PR, Symonds HW. The effect of copper and heliotrope on the composition of bile in sheep. Res Vet Sci. 1992;53(3):324–330.
47. Albers CJ, Huizenga JR, Krom RA, Vonk RJ, Gips CH. Composition of human hepatic bile. Ann Clin Biochem. 1985;22 ( Pt 2)129–
36. Hultcrantz R, Glaumann H. Studies on the
rat liver following iron overload: biochemi- 132.
cal studies after iron mobilization. Lab
Investig. 1982;46(4):383–392.
37. Drummond GS, Rosenberg DW, Kappas A.
Intestinal heme oxygenase inhibition and increased biliary iron excretion by metallo- porphyrins. Gastroenterology. 1992;102(4 Pt 1):1170–1175.
38. Schümann K, Schäfer SG, Forth W. Iron absorption and biliary excretion of transfer- rin in rats. Res Exp Med (Berl.) 1986;186 (3):215–219.
39. Zanninelli G, Choudury R, Loréal O, et al. Novel orally active iron chelators (3- hydroxypyridin-4-ones) enhance the bil- iary excretion of plasma non-transferrin- bound iron in rats. J Hepatol 1997;27(1): 176–184.
40. Brissot P, Zanninelli G, Guyader D, Zeind J, Gollan J. Biliary excretion of plasma non- transferrin-bound iron in rats: pathogenetic importance in iron-overload disorders. Am J Physiol. 1994;267(1 Pt 1):G135-142.
41. Dijkstra M, Kuipers F, Smit EP, de Vries JJ, Havinga R, Vonk RJ. Biliary secretion of trace elements and minerals in the rat. Effects of bile flow variation and diurnal rhythms. J Hepatol. 1991;13(1):112–119.
42. Allain P, Leblondel G, Mauras Y. Effect of aluminum and deferoxamine on biliary iron elimination in the rat. Proc Soc Exp Biol Med. 1988;188(4):471–473.
43. Brissot P, Deugnier Y, Guyader D, et al. Iron overload and the biliary route. Adv Exp Med Biol. 1994;356277–283.
44. Hall ED, Symonds HW. The maximum capacity of the bovine liver to excrete man- ganese in bile, and the effects of a man-
48. Cikrt M, Ponka P, Necas E, Neuwirt J. Biliary iron excretion in rats following pyri- doxal isonicotinoyl hydrazone. Br J Haematol. 1980;45(2):275–283.
49. Gooneratne SR, Chaplin RK, Trent AM, Christensen DA. Effect of tetrathiomolyb- date administration on the excretion of copper, zinc, iron and molybdenum in sheep bile. Br Vet J. 1989;145(1):62–72.
50. Lévy P, Dumont M, Brissot P, et al. Acute infusions of bile salts increase biliary excre- tion of iron in iron-loaded rats. Gastroenterology. 1991;101(6):1673–1679.
51. LeSage GD, Kost LJ, Barham SS, LaRusso NF. Biliary excretion of iron from hepato- cyte lysosomes in the rat. A major excreto- ry pathway in experimental iron overload. J Clin Invest. 1986;77(1):90–97.
52. Hultcrantz R, Angelin B, Björn-Rasmussen E, Ewerth S, Einarsson K. Biliary excretion of iron and ferritin in idiopathic hemochro- matosis. Gastroenterology. 1989;96(6): 1539–1545.
53. Prasnicka A, Cermanova J, Hroch M, et al. Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. Biochim Biophys Acta. 2017;1862(12): 1469–1480.
54. Brissot P, Bolder U, Schteingart CD, Arnaud J, Hofmann AF. Intestinal absorption and enterohepatic cycling of biliary iron originat- ing from plasma non-transferrin-bound iron in rats. Hepatology. 1997;25(6):1457–1461.
55. Iancu TC, Shiloh H, Raja KB, et al. The hypotransferrinaemic mouse: ultrastructur- al and laser microprobe analysis observa- tions. J Pathol. 1995;177(1):83–94.
haematologica | 2019; 104(4)
689