Page 86 - Haematologica August 2018

D. Salvatore et al.
Table 3. Results of multivariate analysis of main outcomes after HSCT in the entire population (A) and in patients with intermediate (B) or high
risk (c) AML.
A) Variable
RI
Haplo versus. MSD
Age (incremental age of 10 years)
Year of allo-HSCT
RIC versus MAC
PBSC versus BM
Female to male recipient versus other Patient CMV seropositivity
Donor CMV seropositivity
Poor cytogenetics versus other
Time from diagnosis to allo-HSCT > median
NRM
Haplo versus MSD
Age (incremental age of 10 years)
Year of allo-HSCT
RIC versus MAC
PBSC versus BM
Female to male recipient versus other Patient CMV seropositivity
Donor CMV seropositivity
Poor cytogenetics versus other
Time from diagnosis to allo-HSCT > median
LFS
Haplo versus MSD
Age (incremental age of 10 years)
Year of allo-HSCT
RIC versus MAC
PBSC versus BM
Female to male recipient versus other Patient CMV seropositivity
Donor CMV seropositivity
Poor cytogenetics versus other
Time from diagnosis to allo-HSCT > median
OS
Haplo versus MSD
Age (incremental age of 10 years)
Year of allo-HSCT
RIC versus MAC
PBSC versus BM
Female to male recipient versus other Patient CMV seropositivity
Donor CMV seropositivity
Poor cytogenetics versus other
Time from diagnosis to allo-HSCT > median
GRFS
Haplo versus MSD
Age (incremental age of 10 years) Year of allo-HSCT
RIC versus MAC
PBSC versus BM
HR (95% CI) P
0.86 (0.60-1.22) 0.41 1.03 (0.97-1.11) 0.27 1.00 (0.97-1.04) 0.62 1.12 (0.93-1.34) 0.21 0.95 (0.78-1.17) 0.66 0.91 (0.76-1.09) 0.33 1.07 (0.90-1.27) 0.43 0.90 (0.76-1.05) 0.20
1.90 (1.62-2.22) 0.94 (0.90-0.98)
<0.01 <0.01
2.56 (1.73-3.77)
1.24 (1.11-1.37)
0.96 (0.92-1.01) 0.17 0.79 (0.61-1.03) 0.08 0.98 (0.73-1.31) 0.89 1.33 (1.05-1.67) 0.01 1.22 (0.93-1.59) 0.13 1.28 (1.00-1.64) 0.04 1.03 (0.79-1.34) 0.79 1.00 (0.96-1.05) 0.76
1.33 (1.03-1.71)
1.09 (1.03-1.16)
0.99 (0.97-1.02) 0.76 1.00 (0.86-1.16) 0.93 0.96 (0.81-1.13) 0.65 1.04 (0.91-1.20) 0.50 1.11 (0.96-1.29) 0.13 1.00 (0.87-1.15) 0.94
<0.01 <0.01
1322
1.59 (1.39-1.81)
0.97 (0.94-1.00) 0.08
1.34 (1.03-1.75)
1.15 (1.08-1.22)
0.99 (0.96-1.02) 0.71 0.94 (0.81-1.09) 0.45 1.04 (0.88-1.23) 0.60 1.09 (0.94-1.27) 0.21 1.15 (0.99-1.34) 0.06 1.01 (0.87-1.16) 0.87
<0.04 <0.01
<0.01
1.71 (1.49-1.97)
0.97 (0.94-1.01) 0.17
1.17 (0.92-1.48) 0.18
1.07 (1.01-1.12)
0.98 (0.96-1.00) 0.12 0.90 (0.79-1.03) 0.14 1.07 (0.92-1.24) 0.36
<0.04 <0.01
<0.01
<0.01
continued on the next page
haematologica | 2018; 103(8)