Page 143 - 2022_03-Haematologica-web
P. 143
Patterns of genetic alterations in B-NHL
haematologica | 2022; 107(3)
699
A
B
Figure 6. Cumulative acquisition of co-occurring genetic alterations. (A) An oncoplot shows the presence or absence of genetic alterations according to their clusters of co-association in molecularly-defined Burkitt lymphoma, activated B- cell-like diffuse large B-cell lymphoma (DLBCL), germinal center B-cell-like DLBCL, follicular lymphoma and mantle cell lymphoma with available gene expression microarray data. Shading shows histological or molecular subtypes with ≥50% of tumors bearing ≥2 genetic alterations within a given cluster. (B) Bar plots shows the frequency of tumors with ≥2 genetic alterations from each cluster. mBL: molecularly-defined Burkitt lymphoma; ABC: activated B-cell-like DLBCL; COO: cell of origin; GCB: germinal center B-cell-like DLBCL; FL: follicular lymphoma; MCL: mantle cell lymphoma.
