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Patterns of genetic alterations in B-NHL
Figure 4. Subtype-specific clusters of co-occurring genetic alterations. The frequency (bar graph) and over- or under-representation (blue to red scale) of mutations and structural alterations is shown on the left for Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. The correlation matrix of co-associated (green) and mutually exclusive (purple) relationships was clustered to identify seven groups of co-occurring genetic alterations that were pre- dominantly over-represented in a single subtype of B-cell non-Hodgkin lymphoma. BL: Burkitt lymphoma; DLBCL: diffuse large B-cell lymphoma; FL: follicular lym- phoma; MCL: mantle cell lymphoma
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