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Figure 8. The combination of APR-246 with SLC7A11 inhibition has synergistic anti-leukemic effects in acute myeloid leukemia in vivo. (A) Design of the in vivo experiment. (B) Representative flow cytometry analysis of bone marrow cells marked with mCD45.1 and hCD45 from each treatment subgroup. (C) Viable mCD45.1- hCD45+ hCD33+ cell counts in the bone marrow of the different treatment subgroups. Bars represent mean of all experiments and errors denote ± standard devia- tions. Statistics by t-test; *P<0.05, **P<0.01, ***P<0.0001.
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