Page 185 - 2022_01-Haematologica-web

VDAC-driven mitophagy in human erythropoiesis
and activates latent Parkin for mitophagy. J
Cell Biol. 2010;189(2):211-221.
16. Ordureau A, Paulo JA, Zhang W, et al.
Dynamics of PARKIN-dependent mitochon- drial ubiquitylation in induced neurons and model systems revealed by digital snapshot proteomics. Mol Cell. 2018;70(2):211-227.
17. Narendra DP, Jin SM, Tanaka A, et al. PINK1 is selectively stabilized on impaired mito- chondria to activate Parkin. PLoS Biol. 2010;8(1):e1000298.
18. Sun Y, Vashisht AA, Tchieu J, Wohlschlegel JA, Dreier L. Voltage-dependent anion chan- nels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem. 2012;287(48): 40652-40660.
19. Geisler S, Holmstrom KM, Skujat D, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 2010;12(2):119-131.
20. Gatliff J, East D, Crosby J, et al. TSPO inter- acts with VDAC1 and triggers a ROS-medi- ated inhibition of mitochondrial quality con- trol. Autophagy. 2014;10(12):2279-2296.
21. Shoshan-Barmatz V, Keinan N, Abu-Hamad S, Tyomkin D, Aram L. Apoptosis is regulat- ed by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo. Biochim Biophys Acta. 2010;1797(6-7):1281- 1291.
22.Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apop- togenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999;399(6735): 483-487.
23. Rone MB, Midzak AS, Issop L, et al. Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hor- mones. Mol Endocrinol. 2012;26(11):1868- 1882.
24. Lee AC, Xu X, Colombini M. The role of pyridine dinucleotides in regulating the per- meability of the mitochondrial outer mem- brane. J Biol Chem. 1996;271(43):26724- 26731.
25. Rostovtseva TK, Komarov A, Bezrukov SM, Colombini M. VDAC channels differentiate between natural metabolites and synthetic molecules. J Membr Biol. 2002;187(2):147- 156.
26. An X, Schulz VP, Li J, et al. Global transcrip- tome analyses of human and murine termi- nal erythroid differentiation. Blood. 2014; 123(22):3466-3477.
27. Gautier EF, Ducamp S, Leduc M, Salnot V, Guillonneau F, Dussiot M, et al. Comprehensive proteomic analysis of human erythropoiesis. Cell Rep. 2016;16(5): 1470-1484.
28. Hu J, Liu J, Xue F, et al. Isolation and func- tional characterization of human erythrob- lasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo. Blood. 2013;121(16): 3246-3253.
29. Konstantinidis DG, Pushkaran S, Johnson JF, et al. Signaling and cytoskeletal require- ments in erythroblast enucleation. Blood. 2012;119(25):6118-6127.
30. Wang J, Ramirez T, Ji P, Jayapal SR, Lodish HF, Murata-Hori M. Mammalian erythrob- last enucleation requires PI3K-dependent cell polarization. J Cell Sci. 2012;125(Pt 2):340-349.
31. Gasko O, Danon D. Deterioration and dis- appearance of mitochondria during reticulo- cyte maturation. Exp Cell Res. 1972;75(1):159-169.
32. Simpson CF, Kling JM. The mechanism of mitochondrial extrusion from phenylhy- drazine-induced reticulocytes in the circulat- ing blood. J Cell Biol. 1968;36(1):103-109.
33. Beams HW, Kessel RG. Electron microscope and ultracentrifugation studies on the rat reticulocyte. Am J Anat. 1966;118(2):471- 507.
34.Bantug GR, Fischer M, Grahlert J, et al. Mitochondria-endoplasmic reticulum con- tact sites function as immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells. Immunity. 2018;48(3):542-555.e6.
35.Pankiv S, Clausen TH, Lamark T, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated pro- tein aggregates by autophagy. J Biol Chem. 2007;282(33):24131-24145.
36. Vo MT, Smith BJ, Nicholas J, Choi YB. Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus. Nat Commun. 2019;10(1):3203.
37. Liu X, Zhang Y, Ni M, et al. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nat Cell Biol. 2017;19(6):626-638.
38. Moras M, Hattab C, Gonzalez-Menendez P, et al. Downregulation of mitochondrial TSPO inhibits mitophagy and reduces enu- cleation during human terminal erythro- poiesis. Int J Mol Sci. 2020;21(23):9066.
39. Yang C, Hashimoto M, Lin QXX, Tan DQ, Suda T. Sphingosine-1-phosphate signaling modulates terminal erythroid differentiation through the regulation of mitophagy. Exp Hematol. 2019;72:47-59.
40. Gilquin B, Taillebourg E, Cherradi N, et al. The AAA+ ATPase ATAD3A controls mito- chondrial dynamics at the interface of the inner and outer membranes. Mol Cell Biol. 2010;30(8):1984-1996.
41.
42.
43.
44.
45.
46.
Jin G, Xu C, Zhang X, et al. Atad3a sup- presses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic pro- genitor cells. Nat Immunol. 2018;19(1):29- 40.
Greene AW, Grenier K, Aguileta MA, et al. Mitochondrial processing peptidase regu- lates PINK1 processing, import and Parkin recruitment. EMBO Rep. 2012;13(4):378- 385.
Heo JM, Harper NJ, Paulo JA, et al. Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophago- some synapse during PARK2-dependent mitophagy. Sci Adv. 2019;5(11):eaay4624. Hoshino A, Wang WJ, Wada S, et al. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019;575(7782):375-379.
Traxler EA, Thom CS, Yao Y, Paralkar V, Weiss MJ. Nonspecific inhibition of erythro- poiesis by short hairpin RNAs. Blood. 2018;131(24):2733-2736.
Lupo F, Tibaldi E, Matte A, et al. A new molecular link between defective autophagy and erythroid abnormalities in chorea-acan- thocytosis. Blood. 2016;128(25):2976-2987.
47. Jagadeeswaran R, Vazquez BA, Thiruppathi M, et al. Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease. Exp Hematol. 2017;50:46-52.
48.Jiang H, Yang L, Guo L, et al. Impaired mitophagy of nucleated erythroid cells leads to anemia in patients with myelodysplastic syndromes. Oxid Med Cell Longev. 2018;2018:6328051.
49. Sbardella D, Tundo GR, Campagnolo L, et al. Retention of mitochondria in mature human red blood cells as the result of autophagy impairment in Rett syndrome. Sci Rep. 2017;7(1):12297.
50. WuL,XuW,XuL,KongQ,FangJ. Mitophagy is increased during erythroid dif- ferentiation in beta-thalassemia. Int J Hematol. 2017;105(2):162-173.
51. Li-Harms X, Milasta S, Lynch J, et al. Mito- protective autophagy is impaired in ery- throid cells of aged mtDNA-mutator mice. Blood. 2015;125(1):162-174.
52. Houwerzijl EJ, Pol HW, Blom NR, van der Want JJ, de Wolf JT, Vellenga E. Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructur- al features of enhanced autophagy of mitochondria. Leukemia. 2009;23(5):886- 891.
53. Koschade SE, Brandts CH. Selective autophagy in normal and malignant hematopoiesis. J Mol Biol. 2020;432(1):261- 282.
haematologica | 2022; 107(1)
177